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DOC2B gene

Known as: DOC2B, DOUBLE C2-LIKE DOMAIN-CONTAINING PROTEIN, BETA, double C2 domain beta 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
DOC2B promotes insulin sensitivity in mice via a novel KLC1-dependent mechanism in skeletal muscle
Aims/hypothesisSkeletal muscle accounts for >80% of insulin-stimulated glucose uptake; dysfunction of this process underlies… 
2018
2018
Doc2b Protects β-Cells Against Inflammatory Damage and Enhances Function
Loss of functional β-cell mass is an early feature of type 1 diabetes. To release insulin, β-cells require soluble N… 
Review
2018
Review
2018
DOC 2 B Levels in New-onset Type 1 Diabetes Exocytosis Protein DOC 2 B as a Biomarker of Type 1 Diabetes
Advance Articles are PDF versions of manuscripts that have been peer reviewed and accepted but not yet copyedited. The… 
2014
2014
DOC2 isoforms play dual roles in insulin secretion and insulin-stimulated glucose uptake
Aims/hypothesisGlucose-stimulated insulin secretion (GSIS) and insulin-stimulated glucose uptake are processes that rely on… 
2014
2014
DOC2B and Munc13-1 differentially regulate neuronal network activity.
Alterations in the levels of synaptic proteins affect synaptic transmission and synaptic plasticity. However, the precise effects… 
2013
2013
Doc2b promotes GLUT4 exocytosis by activating the SNARE-mediated fusion reaction in a calcium- and membrane bending–dependent manner
Reconstitution of GLUT4 vesicle fusion in a defined fusion system shows that the C2-domain factor Doc2b activates the SNARE… 
2013
2013
DNA Methylation Changes in Clinical Stages of Oral Cancer Progression and Correlation with DOC2B Promoter Hypermethylation
The well-established correlation between global DNA hypomethylation and genomic instability offers one of the mechanistic… 
2012
2012
Doc2b Is a Key Effector of Insulin Secretion and Skeletal Muscle Insulin Sensitivity
Exocytosis of intracellular vesicles, such as insulin granules, is carried out by soluble N-ethylmaleimide-sensitive factor… 
Highly Cited
2009
Highly Cited
2009
DOC2B: A Novel Syntaxin-4 Binding Protein Mediating Insulin-Regulated GLUT4 Vesicle Fusion in Adipocytes
OBJECTIVE— Insulin stimulates glucose uptake in skeletal muscle and adipose tissues primarily by stimulating the translocation of… 
2009
2009
DOC2b is a SNARE regulator of glucose-stimulated delayed insulin secretion.
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