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DNAJC19 gene

Known as: Tim14, DnaJ heat shock protein family (Hsp40) member C19, DNAJC19 
 
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
DNAJC19, a mitochondrial cochaperone associated with cardiomyopathy, forms a complex with prohibitins to regulate cardiolipin remodeling.
Prohibitins form large protein and lipid scaffolds in the inner membrane of mitochondria that are required for mitochondrial… Expand
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2014
2014
Remodelling of the active presequence translocase drives motor-dependent mitochondrial protein translocation.
Proteins with N-terminal targeting signals are transported across the inner mitochondrial membrane by the presequence translocase… Expand
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2014
2014
Unraveling the intricate organization of mammalian mitochondrial presequence translocases: existence of multiple translocases for maintenance of mitochondrial function.
Mitochondria are indispensable organelles implicated in multiple aspects of cellular processes, including tumorigenesis. Heat… Expand
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2007
2007
Association of the Tim14.Tim16 subcomplex with the TIM23 translocase is crucial for function of the mitochondrial protein import motor.
Tim14 and Tim16 are essential components of the import motor of the mitochondrial TIM23 preprotein translocase. Tim14 contains a… Expand
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Highly Cited
2006
Highly Cited
2006
Identification of Tam41 maintaining integrity of the TIM23 protein translocator complex in mitochondria
Newly synthesized mitochondrial proteins are imported into mitochondria with the aid of protein translocator complexes in the… Expand
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Highly Cited
2005
Highly Cited
2005
Mutation of DNAJC19, a human homologue of yeast inner mitochondrial membrane co-chaperones, causes DCMA syndrome, a novel autosomal recessive Barth syndrome-like condition.
BACKGROUND A novel autosomal recessive condition, dilated cardiomyopathy with ataxia (DCMA) syndrome, has been identified in the… Expand
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Highly Cited
2005
Highly Cited
2005
Pam17 is required for architecture and translocation activity of the mitochondrial protein import motor.
Import of mitochondrial matrix proteins involves the general translocase of the outer membrane and the presequence translocase of… Expand
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2005
2005
Role of Pam16's degenerate J domain in protein import across the mitochondrial inner membrane.
Translocation of proteins across the mitochondrial inner membrane is an essential process requiring an import motor having… Expand
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2005
2005
Conserved N-terminal negative charges in the Tim17 subunit of the TIM23 translocase play a critical role in the import of preproteins into mitochondria.
The TIM23 complex of the mitochondrial inner membrane mediates the import of preproteins that contain positively charged… Expand
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Highly Cited
2004
Highly Cited
2004
Pam16 has an essential role in the mitochondrial protein import motor
Mitochondrial preproteins destined for the matrix are translocated by two channel-forming transport machineries, the translocase… Expand
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