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DNA ligase I

Known as: DNA Ligase 1, Polydeoxyribonucleotide Synthase [ATP] 1, Ligase I, DNA 
DNA ligase 1 (919 aa, ~102 kDa) is encoded by the human LIG1 gene. This protein plays a role in DNA replication and repair of nicks in double… 
National Institutes of Health

Related topics

Related topics

9 relations
DNA LigasesDNA ReplicationEnzyme GeneHomo sapiens

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
The Transcriptional Response to DNA-Double-Strand Breaks in Physcomitrella patens
The model bryophyte Physcomitrella patens is unique among plants in supporting the generation of mutant alleles by facile… 
2007
2007
Human DNA ligase IV and the ligase IV/XRCC4 complex: analysis of nick ligation fidelity.
In addition to linking nicked/fragmented DNA molecules back into a contiguous duplex, DNA ligases also have the capacity to… 
2007
2007
A Conserved Physical and Functional Interaction between the Cell Cycle Checkpoint Clamp Loader and DNA Ligase I of Eukaryotes*
DNA ligase I joins Okazaki fragments during DNA replication and completes certain excision repair pathways. The participation of… 
Highly Cited
2006
Highly Cited
2006
An evolutionarily conserved translation initiation mechanism regulates nuclear or mitochondrial targeting of DNA ligase 1 in Arabidopsis thaliana.
The Arabidopsis DNA ligase 1 gene (AtLIG1) is indispensable for cell viability. AtLIG1 expresses one major and two minor mRNA… 
2004
2004
Choice of a start codon in a single transcript determines DNA ligase 1 isoform production and intracellular targeting in Arabidopsis thaliana.
DNA ligase 1 (AtLIG1) is the only essential DNA ligase activity in Arabidopsis and is implicated in the important processes of… 
2003
2003
Cell Cycle-dependent Phosphorylation of Human DNA Ligase I at the Cyclin-dependent Kinase Sites*
We have described previously that, during S-phase, human DNA ligase I is phosphorylated on Ser66, a casein kinase II site. Here… 
Highly Cited
1997
Highly Cited
1997
Specific Function of DNA Ligase I in Simian Virus 40 DNA Replication by Human Cell-free Extracts Is Mediated by the Amino-terminal Non-catalytic Domain*
The joining of Okazaki fragments during lagging strand DNA replication in mammalian cells is believed to be due to DNA ligase I… 
Highly Cited
1994
Highly Cited
1994
Mammalian DNA ligase II is highly homologous with vaccinia DNA ligase. Identification of the DNA ligase II active site for enzyme-adenylate formation.
Highly Cited
1993
Highly Cited
1993
V(D)J recombination in ataxia telangiectasia, Bloom's syndrome, and a DNA ligase I-associated immunodeficiency disorder.
Highly Cited
1991
Highly Cited
1991
In vitro mutagenesis and functional expression in Escherichia coli of a cDNA encoding the catalytic domain of human DNA ligase I.
Human cDNAs encoding fragments of DNA ligase I, the major replicative DNA ligase in mammalian cells, have been expressed as lacZ… 
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