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DNA ligase I

Known as: DNA Ligase 1, Polydeoxyribonucleotide Synthase [ATP] 1, Ligase I, DNA 
DNA ligase 1 (919 aa, ~102 kDa) is encoded by the human LIG1 gene. This protein plays a role in DNA replication and repair of nicks in double… 
National Institutes of Health

Related topics

Related topics

9 relations
DNA LigasesDNA ReplicationEnzyme GeneHomo sapiens

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Defects in DNA Ligase I Trigger PCNA Ubiquitination at Lysine 107
In all eukaryotes, the ligation of newly synthesized DNA, also known as Okazaki fragments, is catalysed by DNA ligase I (ref. 1… 
2007
2007
Human DNA ligase IV and the ligase IV/XRCC4 complex: analysis of nick ligation fidelity.
In addition to linking nicked/fragmented DNA molecules back into a contiguous duplex, DNA ligases also have the capacity to… 
2004
2004
Choice of a start codon in a single transcript determines DNA ligase 1 isoform production and intracellular targeting in Arabidopsis thaliana.
DNA ligase 1 (AtLIG1) is the only essential DNA ligase activity in Arabidopsis and is implicated in the important processes of… 
Highly Cited
2002
Highly Cited
2002
DNA ligase I null mouse cells show normal DNA repair activity but altered DNA replication and reduced genome stability.
DNA ligase I is the key ligase for DNA replication in mammalian cells and has also been reported to be involved in a number of… 
Highly Cited
2001
Highly Cited
2001
DNA Ligase I and Proliferating Cell Nuclear Antigen Form a Functional Complex*
DNA ligase I is responsible for joining Okazaki fragments during DNA replication. An additional proposed role for DNA ligase I is… 
Highly Cited
2001
Highly Cited
2001
Elevated expression of DNA ligase I in human cancers.
PURPOSE Human DNA ligase I plays an essential role in DNA replication, recombination, and repair by catalyzing the formation of… 
Highly Cited
1997
Highly Cited
1997
An interaction between DNA ligase I and proliferating cell nuclear antigen: implications for Okazaki fragment synthesis and joining.
Although three human genes encoding DNA ligases have been isolated, the molecular mechanisms by which these gene products… 
Highly Cited
1994
Highly Cited
1994
Aberrant DNA repair and DNA replication due to an inherited enzymatic defect in human DNA ligase I
Two missense mutations in different alleles of the DNA ligase I gene have been described in a patient (46BR) with… 
Highly Cited
1992
Highly Cited
1992
DNA ligase I from Saccharomyces cerevisiae: physical and biochemical characterization of the CDC9 gene product.
Genetic studies have previously demonstrated that the Saccharomyces cerevisiae CDC9 gene product, which is functionally… 
Highly Cited
1991
Highly Cited
1991
In vitro mutagenesis and functional expression in Escherichia coli of a cDNA encoding the catalytic domain of human DNA ligase I.
Human cDNAs encoding fragments of DNA ligase I, the major replicative DNA ligase in mammalian cells, have been expressed as lacZ… 
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