DNA end binding

Interacting selectively and non-covalently with the ends of DNA that are exposed by the creation of double-strand breaks (DSBs). [GOC:jl]
National Institutes of Health

Topic mentions per year

Topic mentions per year

1994-2016
02419942016

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2014
2014
The Mre11-Rad50 complex is highly conserved, yet the mechanisms by which Rad50 ATP-driven states regulate the sensing, processing… (More)
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2005
2005
We examined the equilibrium binding of Escherichia coli RecBC and RecBCD helicases to duplex DNA ends possessing pre-existing… (More)
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2001
2001
Fanconi anemia (FA) is a genetic disorder associated with genomic instability and cancer predisposition. Cultured cells from FA… (More)
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1997
1997
Heterodimers of the 70 and 80 kDa Ku autoantigens (Ku70 and Ku80) activate the DNA-dependent protein kinase (DNA-PK). Mutations… (More)
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Highly Cited
1996
Highly Cited
1996
DNA double-strand break (DSB) repair in mammalian cells is dependent on the Ku DNA binding protein complex. However, the… (More)
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1996
1996
DNA ends are generated during double-strand-break repair and recombination. A p70-p86 heterodimer, Ku, accounts for the DNA end… (More)
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Highly Cited
1996
Highly Cited
1996
Ku is a heterodimeric DNA end binding complex composed of 70 and 86 kDa subunits. Here, we show that Ku86 is essential for normal… (More)
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Highly Cited
1995
Highly Cited
1995
DNA-dependent protein kinase (DNA-PK) is a nuclear serine/threonine protein kinase composed of a catalytic subunit called p350… (More)
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1995
1995
Two ionizing radiation-sensitive (IRs) and DNA double-strand break (DSB) mutants, sxi-3 and sxi-2, were shown to be severely… (More)
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1994
1994
Double-strand DNA break repair is important in maintaining the genetic integrity of the genome. Using a mobility shift assay, we… (More)
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