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DNA Damage Response Deficiency

Known as: DNA Damage Repair Deficiency, DNA Damage Response and Repair Deficiency, DDRD 
A decrease in the ability of cells to respond to damaged DNA and to repair the damage. This DNA repair deficiency can be caused by mutations in the… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Whole exome sequencing-based analysis to identify DNA damage repair deficiency as a major contributor to gliomagenesis in adult diffuse gliomas.
Objective Processes that cause or contribute to cancer, such as aging, exposure to carcinogens, or DNA damage repair deficiency… 
2018
2018
The Potential of Using DNA Damage Repair Deficiency As a Biomarker for Cytarabine Response in AML Patients
Acute Myeloid Leukemia (AML) is most commonly seen in people over the age of 65 and has a median age of 63. Globally there is… 
2017
2017
Impact of DNA repair deficiency signature on outcomes in triple negative breast cancer (TNBC) patients treated with AC chemotherapy (SWOG S9313).
529Background: Biomarkers of response and resistance to adjuvant chemotherapy for TNBC are needed. Deficiency in DNA damage… 
2017
2017
Association of a DNA damage response deficiency (DDRD) assay with prognosis in resected esophageal and gastric adenocarcinoma.
4026Background: Current strategies to guide the selection of neo-adjuvant or adjuvant therapy in esophageal and gastric… 
2016
2016
Different ratio spectra methods for simultaneous determination of Olmesartan Medoxomil , Hydrochlorothiazide and Amlodipine Besylate
New, simple and specific spectrophotometric methods involving Direct spectrophotometric method ,derivative ratio spectra-zero… 
2016
2016
Abstract 4000: A DNA damage response deficiency (DDRD) group in breast cancer is associated with activation of the STING innate immune pathway and PD-L1 expression
We have previously identified a DNA damage response deficient (DDRD) subgroup in breast cancer, associated with loss of the… 
2016
2016
Abstract OT3-02-07: Neo-DDRD: A biomarker-driven neoadjuvant feasibility study in breast cancer
Background Anthracycline-based chemotherapy reduces the risk of early breast cancer recurrence but to date it has not been… 
2014
2014
Association of a DNA Damage Response Deficiency (DDRD) assay and prognosis in early stage Oesophageal Adenocarcinoma
4015 Background: The incidence of esophageal adenocarcinoma (EAC) has increased 6-fold in the last 30 years and in early stage… 
2014
2014
Validated or not validated? That is the question.
deviation estimates were … acceptable as they are <5% of the … reportable range” (page 24 of Supplementary Data). Although this… 
2011
2011
Identification of a novel breast cancer molecular subgroup associated with a deficiency in DNA-damage response.
10511 Background: Loss of a functional DNA-damage response (DDR) sensitizes tumors to DNA-damaging as well as targeted… 
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