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DNA, Catalytic

Known as: DNA, Catalytic [Chemical/Ingredient], DNAzyme, Catalytic DNA 
Molecules of DNA that possess enzymatic activity.
National Institutes of Health

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DNAzyme, 9(25)-11tDz13 DNAzymeRNA-cleaving DNA 8-17
In BloodProcess of secretionantagonists & inhibitorsaspects of radiation effects

Papers overview

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Highly Cited
2015
Highly Cited
2015
A smart DNAzyme-MnO₂ nanosystem for efficient gene silencing.
DNAzymes hold promise for gene-silencing therapy, but the lack of sufficient cofactors in the cell cytoplasm, poor membrane… 
Highly Cited
2013
Highly Cited
2013
A DNAzyme-gold nanoparticle probe for uranyl ion in living cells.
DNAzymes have shown great promise as a general platform for detecting metal ions, as many metal-specific DNAzymes can be obtained… 
Highly Cited
2009
Highly Cited
2009
Abasic site-containing DNAzyme and aptamer for label-free fluorescent detection of Pb(2+) and adenosine with high sensitivity, selectivity, and tunable dynamic range.
An abasic site called dSpacer has been introduced into duplex regions of the 8-17 DNAzyme and adenosine aptamer for label-free… 
Highly Cited
2008
Highly Cited
2008
A highly selective DNAzyme sensor for mercuric ions.
Highly Cited
2007
Highly Cited
2007
Rational design of "turn-on" allosteric DNAzyme catalytic beacons for aqueous mercury ions with ultrahigh sensitivity and selectivity.
Highly Cited
2007
Highly Cited
2007
Amplified analysis of low-molecular-weight substrates or proteins by the self-assembly of DNAzyme-aptamer conjugates.
Blocked aptamer-DNAzyme conjugates act as aptasensors for the amplified analysis of adenosine 5‘-monophosphate or lysozyme. 
Review
2006
Review
2006
Functional DNA nanotechnology: emerging applications of DNAzymes and aptamers.
Highly Cited
2004
Highly Cited
2004
Adenosine-dependent assembly of aptazyme-functionalized gold nanoparticles and its application as a colorimetric biosensor.
Previous work has shown that DNAzyme-directed assembly of gold nanoparticles can be utilized to make effective colorimetric… 
Highly Cited
2004
Highly Cited
2004
Amplified chemiluminescence surface detection of DNA and telomerase activity using catalytic nucleic acid labels.
A G-rich nucleic acid sequence binds hemin and yields a biocatalytic complex (DNAzyme) of peroxidase activity, namely, the… 
Highly Cited
2003
Highly Cited
2003
A lead-dependent DNAzyme with a two-step mechanism.
A detailed biochemical and mechanistic study of in vitro selected variants of 8-17 DNAzymes is presented. Even though the 8-17… 
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