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DESI2 gene

Known as: DESI2, PPPDE1, DESUMOYLATING ISOPEPTIDASE 2 
National Institutes of Health

Papers overview

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2018
2018
PPPDE1 promotes hepatocellular carcinoma development by negatively regulate p53 and apoptosis
We have previously identified that PPPDE1 is a deubiquitinase (DUB) belonging to a cysteine isopeptidase family. Here we sought… 
2017
2017
PPPDE1 is a novel deubiquitinase belonging to a cysteine isopeptidase family.
2017
2017
Combination of DESI2 and IP10 gene therapy significantly improves therapeutic efficacy against murine carcinoma
DESI2 (also known as PNAS-4) is a novel pro-apoptotic gene activated during the early response to DNA damage. We previously… 
2015
2015
High Phosphorylation Status of AKT/mTOR Signal in DESI2-Reduced Pancreatic Ductal Adenocarcinoma
Desumoylating isopeptidase 2 (DESI2) is a recently identified protein with unclear functions. In this study, a total of 132… 
2011
2011
Antitumor effects of PLGA nanoparticles encapsulating the human PNAS-4 gene combined with cisplatin in ovarian cancer.
Human PNAS-4 (hPNAS-4), as a pro-apoptotic gene, can inhibit tumor growth when overexpressed in some malignant cells. Poly… 
2011
2011
PNAS-4 expression and its relationship to p53 in colorectal cancer
PNAS-4 is a novel pro-apoptotic protein activated during the early response to DNA damage; however, the molecular mechanisms and… 
2010
2010
Identification, Characterization, and Effects of Xenopus laevis PNAS-4 Gene on Embryonic Development
Apoptosis plays an important role in embryonic development. PNAS-4 has been demonstrated to induce apoptosis in several cancer… 
2009
2009
PNAS-4, a novel pro-apoptotic gene, can potentiate antineoplastic effects of cisplatin
PurposePNAS-4, a novel pro-apoptotic gene activated during the early response to DNA damage, can inhibit proliferation via… 
2009
2009
Genetic transfer of PNAS‐4 induces apoptosis and enhances sensitivity to gemcitabine in lung cancer
2008
2008
Prokaryotic expression of a novel mouse pro-apoptosis protein PNAS-4 and application of its polyclonal antibodies.
Mouse PNAS-4 (mPNAS-4) has 96% identity with human PNAS-4 (hPNAS-4) in primary sequence and has been reported to be involved in… 
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