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DCTN1 gene

Known as: p150 glued homolog (Drosophila), DYNACTIN 1, DCTN1 
This gene is involved in the modulation of retrograde transport of cytoplasmic organelles and vesicles.
National Institutes of Health

Related topics

Related topics

9 relations
DCTN3 geneDCTN6 geneDynactin Subunit 1, humanHomo sapiens

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Dynactin1 depletion leads to neuromuscular synapse instability and functional abnormalities
Dynactin subunit 1 is the largest subunit of the dynactin complex, an activator of the molecular motor protein complex dynein… 
Review
2017
Review
2017
DCTN1-related neurodegeneration: Perry syndrome and beyond.
2016
2016
DCTN1 p.K56R in progressive supranuclear palsy.
Highly Cited
2015
Highly Cited
2015
Defining neurodegeneration on Guam by targeted genomic sequencing
Amyotrophic lateral sclerosis/parkinsonism–dementia complex has been described in Guam, Western Papua, and the Kii Peninsula of… 
Review
2014
Review
2014
Recent progress in the genetics of motor neuron disease.
Highly Cited
2014
Highly Cited
2014
Identify mutation in amyotrophic lateral sclerosis cases using HaloPlex target enrichment system
Highly Cited
2013
Highly Cited
2013
dnc-1/dynactin 1 Knockdown Disrupts Transport of Autophagosomes and Induces Motor Neuron Degeneration
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons… 
Highly Cited
2010
Highly Cited
2010
What is the clinical significance of SOD1 mutations in amyotrophic lateral sclerosis?
The identification of patients with amyotrophic lateral sclerosis (ALS) within a single family, some with SOD1 mutation, and some… 
2010
2010
Elucidating the genetics and pathology of Perry syndrome
Highly Cited
2006
Highly Cited
2006
Reversible Disruption of Dynactin 1-Mediated Retrograde Axonal Transport in Polyglutamine-Induced Motor Neuron Degeneration
Spinal and bulbar muscular atrophy (SBMA) is a hereditary neurodegenerative disease caused by an expansion of a trinucleotide CAG… 
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