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DAS181

Known as: 273-666-Neuraminidase [273-Methionine] (Actinomyces viscosus Clone DAS181) Fusion Protein With 125-145-Preproamphiregulin (Human), DAS181-F02, Recombinant Cell-Surface Anchored Sialidase DAS181 
A recombinant sialidase fusion protein composed of a sialidase catalytic domain derived from Actinomyces viscosus, a constituent of the normal oral… 
National Institutes of Health

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Related topics

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Broader (1)

Recombinant Fusion Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
1715. A Randomized, Double-Blind, Placebo-Controlled Multicenter Phase 2 Trial to Examine the Effects of DAS181 in Immunocompromised (IC) Patients With Parainfluenza Virus (PIV) Lower Respiratory…
Abstract Background PIV infections are an important cause of morbidity and mortality in IC patients. DAS181, a sialidase fusion… 
Review
2017
Review
2017
Research progress in human infection with avian influenza H7N9 virus
Since the identification of the novel reassortant avian influenza A (H7N9) virus in China in 2013, until Jun 30, 2017, the virus… 
2016
2016
DAS181 Treatment of Severe Parainfluenza Virus 3 Pneumonia in Allogeneic Hematopoietic Stem Cell Transplant Recipients Requiring Mechanical Ventilation
Parainfluenza virus (PIV) may cause life-threatening pneumonia in allogeneic hematopoietic stem cell transplant (HSCT) recipients… 
Review
2016
Review
2016
Host-directed therapies for antimicrobial resistant respiratory tract infections
Purpose of review Antimicrobial-resistant respiratory tract infections (AMR-RTIs) are increasing, presenting important management… 
2016
2016
Treatment of Resistant Influenza Virus Infection in a Hospitalized Patient with Cystic Fibrosis with DAS181, a Host-Directed Antiviral
We report a cystic fibrosis patient infected with influenza 2009H1N1 who had persistent viral shedding and clinical deterioration… 
Review
2015
Review
2015
Clinical Pharmacokinetics of Inhaled Antimicrobials
AbstractAdministration of inhaled antimicrobials affords the ability to achieve targeted drug delivery into the respiratory tract… 
2014
2014
An Investigational Antiviral Drug, DAS181, Effectively Inhibits Replication of Zoonotic Influenza A Virus Subtype H7N9 and Protects Mice From Lethality
Human infections caused by avian influenza A virus type subtype H7N9 have been associated with substantial morbidity and… 
2014
2014
Successful Treatment of Parainfluenza Virus Respiratory Tract Infection With DAS181 in 4 Immunocompromised Children
Background Parainfluenza virus (PIV), a common pediatric pathogen, is associated with significant morbidity in immunocompromised… 
2012
2012
Expanding the armamentarium against respiratory viral infections: DAS181.
Respiratory viral infections result in significant morbidity and mortality in adults and children globally. Influenza, alone, is… 
Review
2010
Review
2010
Antiviral Strategies for Pandemic and Seasonal Influenza
While vaccines are the primary public health response to seasonal and pandemic flu, short of a universal vaccine there are… 
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