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D2HGDH gene

Known as: D2HGDH, D-2-hydroxyglutarate dehydrogenase, MGC25181 
 
National Institutes of Health

Papers overview

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2018
2018
The 2-hydroxyglutaric aciduria (2-HGA) is a rare neurometabolic disorder that leads to the development of brain damage. It is… Expand
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2018
2018
Significance Here, we identify a role for D2HG in the progression of colitis to colon cancer. In a mouse model of colitis… Expand
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2016
2016
During dark-induced senescence isovaleryl-CoA dehydrogenase (IVDH) and D-2-hydroxyglutarate dehydrogenase (D-2HGDH) act as… Expand
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2016
2016
Neighboring genes transcribing in the same direction can form chimeric RNAs via cis-splicing (cis-SAGe). Previously, we reported… Expand
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2015
2015
Isocitrate dehydrogenases (IDH) convert isocitrate to alpha-ketoglutarate (α-KG). In cancer, mutant IDH1/2 reduces α-KG to D2… Expand
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2015
2015
Cancer-associated isocitrate dehydrogenase (IDH) 1 and 2 mutations gain a new activity of reducing α-KG to produce D-2… Expand
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Highly Cited
2011
Highly Cited
2011
d-2-Hydroxyglutarate dehydrogenase (d-2HGDH) catalyzes the specific and efficient oxidation of d-2-hydroxyglutarate (d-2HG) to 2… Expand
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Highly Cited
2011
Highly Cited
2011
Isocitrate dehydrogenases (IDHs) catalyse oxidative decarboxylation of isocitrate to α-ketoglutarate (α-KG). IDH1 functions in… Expand
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2011
2011
Heterozygous mutations in the highly homologous genes encoding cytosolic isocitrate dehydrogenase 1 (IDH1) and mitochondrial… Expand
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2010
2010
We performed molecular, enzyme, and metabolic studies in 50 patients with D‐2‐hydroxyglutaric aciduria (D‐2‐HGA) who accumulated… Expand
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