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D2HGDH gene

Known as: D2HGDH, D-2-hydroxyglutarate dehydrogenase, MGC25181 
National Institutes of Health

Papers overview

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2020
2020
MYC Regulation of D2HGDH and L2HGDH Influences the Epigenome and Epitranscriptome.
2019
2019
Degradation of D-2-hydroxyglutarate in the presence of isocitrate dehydrogenase mutations
D-2-Hydroxyglutarate (D-2-HG) is regarded as an oncometabolite. It is found at elevated levels in certain malignancies such as… 
2018
2018
Computational approach to unravel the impact of missense mutations of proteins (D2HGDH and IDH2) causing D-2-hydroxyglutaric aciduria 2
The 2-hydroxyglutaric aciduria (2-HGA) is a rare neurometabolic disorder that leads to the development of brain damage. It is… 
2016
2016
Recurrent cis-SAGe chimeric RNA, D2HGDH-GAL3ST2, in prostate cancer.
Highly Cited
2015
Highly Cited
2015
D2HGDH regulates alpha-ketoglutarate levels and dioxygenase function by modulating IDH2
Isocitrate dehydrogenases (IDH) convert isocitrate to alpha-ketoglutarate (α-KG). In cancer, mutant IDH1/2 reduces α-KG to D2… 
Review
2014
Review
2014
Metabolic alterations due to IDH1 mutation in glioma: opening for therapeutic opportunities?
Recently heterozygous mutations in the active site of the enzyme isocitrate dehydrogenase 1 (IDH1) were discovered in… 
2013
2013
Prenatal diagnosis of ring chromosome 2 with lissencephaly and 2p25.3 and 2q37.3 microdeletions detected using array comparative genomic hybridization.
2012
2012
IDH1 and IDH2 have critical roles in 2-hydroxyglutarate production in D-2-hydroxyglutarate dehydrogenase depleted cells.
2011
2011
Mutational analysis of D2HGDH and L2HGDH in brain tumours without IDH1 or IDH2 mutations
Heterozygous mutations in the highly homologous genes encoding cytosolic isocitrate dehydrogenase 1 (IDH1) and mitochondrial… 
2009
2009
Evolutionary History of d-Lactate Dehydrogenases: A Phylogenomic Perspective on Functional Diversity in the FAD Binding Oxidoreductase/Transferase Type 4 Family
Lactate dehydrogenases which convert lactate to pyruvate are found in almost every organism and comprise a group of highly… 
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