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Cyclina

 
National Institutes of Health

Papers overview

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2014
2014
Androgen Suppresses the Proliferation of Androgen Receptor-Positive Castration-Resistant Prostate Cancer Cells via Inhibition of Cdk2, CyclinA, and Skp2
The majority of prostate cancer (PCa) patient receiving androgen ablation therapy eventually develop castration-resistant… Expand
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2013
2013
miR-26a and its Target CKS2 Modulate Cell Growth and Tumorigenesis of Papillary Thyroid Carcinoma
BACKGROUND While many studies have shown that levels of miR-26a are lower in papillary thyroid carcinoma (PTC), the role and… Expand
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2013
2013
A novel cyclinE/cyclinA-CDK inhibitor targets p27(Kip1) degradation, cell cycle progression and cell survival: implications in cancer therapy.
p27(Kip1) (p27) binds and inhibits the cyclin E- or cyclin A-associated cyclin-dependent kinases (CDKs)2 and other CDKs, and… Expand
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2011
2011
The induction of KLF5 transcription factor by progesterone contributes to progesterone-induced breast cancer cell proliferation and dedifferentiation.
Progesterone (Pg) promotes normal breast development during pregnancy and lactation and increases the risk of developing basal… Expand
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2010
2010
Arsenic-induced cell proliferation is associated with enhanced ROS generation, Erk signaling and CyclinA expression.
Arsenic is a well-established human carcinogen; however molecular mechanisms to arsenic-induced carcinogenesis are complex and… Expand
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2006
2006
p16 inhibits matrix metalloproteinase-2 expression via suppression of Sp1-mediated gene transcription.
Previous studies demonstrate that p16, a cyclin-dependent kinase inhibitor and a tumor suppressor, may inhibit matrix… Expand
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Highly Cited
2005
Highly Cited
2005
Asiatic acid, a triterpene, induces apoptosis and cell cycle arrest through activation of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways in human breast…
This study first investigates the anticancer effect of asiatic acid in two human breast cancer cell lines, MCF-7 and MDA-MB-231… Expand
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2005
2005
Divergent siblings: E2F2 and E2F4 but not E2F1 and E2F3 induce DNA synthesis in cardiomyocytes without activation of apoptosis.
Proliferation of mammalian cardiomyocytes ceases around birth when a transition from hyperplastic to hypertrophic myocardial… Expand
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1997
1997
MyoD prevents cyclinA/cdk2 containing E2F complexes formation in terminally differentiated myocytes
Withdrawal from the cell cycle of differentiating myocytes is regulated by the myogenic basic helix – loop – helix (bHLH) protein… Expand
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Highly Cited
1995
Highly Cited
1995
Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex
The crystal structure of the human cyclinA-cyclin-dependent kinase2 (CDK2)-ATP complex has been determined at 2.3 A resolution… Expand
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