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Cyclina

 
National Institutes of Health

Papers overview

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2014
2014
Androgen Suppresses the Proliferation of Androgen Receptor-Positive Castration-Resistant Prostate Cancer Cells via Inhibition of Cdk2, CyclinA, and Skp2
The majority of prostate cancer (PCa) patient receiving androgen ablation therapy eventually develop castration-resistant… Expand
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2013
2013
Chamaejasmine Arrests Cell Cycle, Induces Apoptosis and Inhibits Nuclear NF-κB Translocation in the Human Breast Cancer Cell Line MDA-MB-231
In this study, the anticancer activity of chamaejasmine was characterized in the human breast cancer cell line, MDA-MB-231. Cell… Expand
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2013
2013
A novel cyclinE/cyclinA-CDK inhibitor targets p27(Kip1) degradation, cell cycle progression and cell survival: implications in cancer therapy.
p27(Kip1) (p27) binds and inhibits the cyclin E- or cyclin A-associated cyclin-dependent kinases (CDKs)2 and other CDKs, and… Expand
2013
2013
miR-26a and its Target CKS2 Modulate Cell Growth and Tumorigenesis of Papillary Thyroid Carcinoma
Background While many studies have shown that levels of miR-26a are lower in papillary thyroid carcinoma (PTC), the role and… Expand
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Highly Cited
2010
Highly Cited
2010
Arsenic-induced cell proliferation is associated with enhanced ROS generation, Erk signaling and CyclinA expression.
Arsenic is a well-established human carcinogen; however molecular mechanisms to arsenic-induced carcinogenesis are complex and… Expand
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2006
2006
CDK2/cyclinA inhibitors: targeting the cyclinA recruitment site with small molecules derived from peptide leads.
The syntheses of potent small molecule inhibitors of the CDK2/cyclinA recruitment site are described. Structure-activity trends… Expand
Highly Cited
2005
Highly Cited
2005
Asiatic Acid, a Triterpene, Induces Apoptosis and Cell Cycle Arrest through Activation of Extracellular Signal-Regulated Kinase and p38 Mitogen-Activated Protein Kinase Pathways in Human Breast…
This study first investigates the anticancer effect of asiatic acid in two human breast cancer cell lines, MCF-7 and MDA-MB-231… Expand
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Highly Cited
2005
Highly Cited
2005
Divergent Siblings: E2F2 and E2F4 but not E2F1 and E2F3 Induce DNA Synthesis in Cardiomyocytes Without Activation of Apoptosis
Proliferation of mammalian cardiomyocytes ceases around birth when a transition from hyperplastic to hypertrophic myocardial… Expand
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1997
1997
MyoD prevents cyclinA/cdk2 containing E2F complexes formation in terminally differentiated myocytes
Withdrawal from the cell cycle of differentiating myocytes is regulated by the myogenic basic helix – loop – helix (bHLH) protein… Expand
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Highly Cited
1995
Highly Cited
1995
Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex
The crystal structure of the human cyclinA-cyclin-dependent kinase2 (CDK2)-ATP complex has been determined at 2.3 A resolution… Expand
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