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Cyclic Nucleotide Phosphodiesterases, Type 7

Known as: Phosphodiesterase 7, cAMP Phosphodiesterase-7, Phosphodiesterase-7 
A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC AMP. Several isoforms of the enzyme type exist, each with its own… Expand
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Elevated levels of amyloid beta (Aβ) peptide, hyperphosphorylation of tau protein, and inflammation are pathological hallmarks in… Expand
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2012
2012
Phosphodiesterase (PDE) 7 is involved in proinflammatory processes, being widely expressed both on lymphocytes and on certain… Expand
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2012
2012
A simple and efficient synthetic method for the preparation of quinazoline type phosphodiesterase 7 (PDE7) inhibitors, based on… Expand
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Highly Cited
2011
Highly Cited
2011
BACKGROUND Phosphodiesterase 7 plays a major role in down-regulation of protein kinase A activity by hydrolyzing cAMP in many… Expand
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Review
2005
Review
2005
  • M. Giembycz
  • Proceedings of the American Thoracic Society
  • 2005
  • Corpus ID: 23634887
Phosphodiesterase-4 isoenzymes have absolute specificity for cyclic adenosine-3',5'-monophosphate and are considered potential… Expand
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Highly Cited
2004
Highly Cited
2004
The biochemical and pharmacological characteristics in human proinflammatory cells of BRL 50481 [3-(N,N-dimethylsulfonamido)-4… Expand
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Highly Cited
2002
Highly Cited
2002
Even though the existence of phosphodiesterase (PDE) 7 in T cells has been proved, the lack of a selective PDE7 inhibitor has… Expand
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2001
2001
A CoMFA study of benzo- and benzothienothiadiazines derivatives as phosphodiesterase 7 inhibitors has been carried out in order… Expand
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Highly Cited
2000
Highly Cited
2000
The synthesis of a new family of benzyl derivatives of 2,1,3-benzo- and benzothieno[3,2-a]thiadiazine 2,2-dioxides was achieved… Expand
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Highly Cited
1999
Highly Cited
1999
Costimulation of both the CD3 and CD28 receptors is essential for T cell activation. Induction of adenosine 3',5'-monophosphate… Expand
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