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Cyclic Nucleotide Phosphodiesterases, Type 7

Known as: Phosphodiesterase 7, cAMP Phosphodiesterase-7, Phosphodiesterase-7 
A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC AMP. Several isoforms of the enzyme type exist, each with its own… Expand
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Elevated levels of amyloid beta (Aβ) peptide, hyperphosphorylation of tau protein, and inflammation are pathological hallmarks in… Expand
2013
2013
During the development of the central nervous system (CNS), oligodendrocyte precursors (OPCs) are generated in specific sites… Expand
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Highly Cited
2012
Highly Cited
2012
A simple and efficient synthetic method for the preparation of quinazoline type phosphodiesterase 7 (PDE7) inhibitors, based on… Expand
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Highly Cited
2011
Highly Cited
2011
BACKGROUND Phosphodiesterase 7 plays a major role in down-regulation of protein kinase A activity by hydrolyzing cAMP in many… Expand
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Highly Cited
2008
Highly Cited
2008
Cyclic nucleotide phosphodiesterase (PDE) isoforms can influence disease pathogenesis and be novel therapeutic targets. Because… Expand
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2008
2008
The second messenger molecule cyclic adenosine monophosphate (cAMP) plays an important role in the hormonal regulation of bone… Expand
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Review
2005
Review
2005
  • M. Giembycz
  • Proceedings of the American Thoracic Society
  • 2005
  • Corpus ID: 23634887
Phosphodiesterase-4 isoenzymes have absolute specificity for cyclic adenosine-3',5'-monophosphate and are considered potential… Expand
Highly Cited
2004
Highly Cited
2004
The biochemical and pharmacological characteristics in human proinflammatory cells of BRL 50481 [3-(N,N-dimethylsulfonamido)-4… Expand
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Highly Cited
2000
Highly Cited
2000
The synthesis of a new family of benzyl derivatives of 2,1,3-benzo- and benzothieno[3,2-a]thiadiazine 2,2-dioxides was achieved… Expand
Highly Cited
1999
Highly Cited
1999
Costimulation of both the CD3 and CD28 receptors is essential for T cell activation. Induction of adenosine 3',5'-monophosphate… Expand