Cyclic Nucleotide Phosphodiesterases, Type 7

Known as: Phosphodiesterase 7, cAMP Phosphodiesterase-7, Phosphodiesterase-7 
A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC AMP. Several isoforms of the enzyme type exist, each with its own… (More)
National Institutes of Health

Papers overview

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2013
2013
During the development of the central nervous system (CNS), oligodendrocyte precursors (OPCs) are generated in specific sites… (More)
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2013
2013
Elevated levels of amyloid beta (Aβ) peptide, hyperphosphorylation of tau protein, and inflammation are pathological hallmarks in… (More)
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2012
2012
A simple and efficient synthetic method for the preparation of quinazoline type phosphodiesterase 7 (PDE7) inhibitors, based on… (More)
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2011
2011
BACKGROUND Phosphodiesterase 7 plays a major role in down-regulation of protein kinase A activity by hydrolyzing cAMP in many… (More)
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2008
2008
  • Lingzhi Zhanga, Fiona Murraya, +8 authors Paul A. Insela
  • 2008
Cyclic nucleotide phosphodiesterase (PDE) isoforms can influence disease pathogenesis and be novel therapeutic targets. Because… (More)
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2008
Review
2005
Review
2005
Phosphodiesterase-4 isoenzymes have absolute specificity for cyclic adenosine-3',5'-monophosphate and are considered potential… (More)
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Highly Cited
2004
Highly Cited
2004
The biochemical and pharmacological characteristics in human proinflammatory cells of BRL 50481 [3-(N,N-dimethylsulfonamido)-4… (More)
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2002
2002
Even though the existence of phosphodiesterase (PDE) 7 in T cells has been proved, the lack of a selective PDE7 inhibitor has… (More)
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Highly Cited
1999
Highly Cited
1999
Costimulation of both the CD3 and CD28 receptors is essential for T cell activation. Induction of adenosine 3',5'-monophosphate… (More)
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