CpG Island Methylator Phenotype

Known as: CIMP, CIMP+ 
A phenotype whereby a subset of tumors are characterized by the simultaneous hypermethylation of multiple promoter-associated CpG islands.
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma.
We have profiled promoter DNA methylation alterations in 272 glioblastoma tumors in the context of The Cancer Genome Atlas (TCGA… (More)
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Highly Cited
2009
Highly Cited
2009
CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer.
BACKGROUND The CpG island methylator phenotype (CIMP), characterised by widespread promoter methylation, is associated with… (More)
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Highly Cited
2009
Highly Cited
2009
CpG island methylator phenotype predicts progression of malignant melanoma.
PURPOSE The CpG island methylator phenotype (CIMP) may be associated with development of malignancy through coordinated… (More)
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Highly Cited
2007
Highly Cited
2007
The CpG island methylator phenotype and chromosomal instability are inversely correlated in sporadic colorectal cancer.
BACKGROUND & AIMS The CpG island methylator phenotype (CIMP) is one of the mechanisms involved in colorectal carcinogenesis (CRC… (More)
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Highly Cited
2007
Highly Cited
2007
Diet and lifestyle factor associations with CpG island methylator phenotype and BRAF mutations in colon cancer.
It has been proposed that dietary factors such as folate, alcohol and methionine may be associated with colon cancer because of… (More)
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Highly Cited
2006
Highly Cited
2006
CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer
Aberrant DNA methylation of CpG islands has been widely observed in human colorectal tumors and is associated with gene silencing… (More)
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Highly Cited
2006
Highly Cited
2006
Association of smoking, CpG island methylator phenotype, and V600E BRAF mutations in colon cancer.
BACKGROUND Cigarette smoking has been associated with microsatellite instability in sporadic colon cancer. Most microsatellite… (More)
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Review
2004
Review
2004
CpG island methylator phenotype in cancer
DNA hypermethylation in CpG-rich promoters is now recognized as a common feature of human neoplasia. However, the pathophysiology… (More)
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Highly Cited
1999
Highly Cited
1999
CpG island methylator phenotype in colorectal cancer.
Aberrant methylation of promoter region CpG islands is associated with transcriptional inactivation of tumor-suppressor genes in… (More)
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Highly Cited
1999
Highly Cited
1999
Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype.
Aberrant methylation of 5' CpG islands is thought to play an important role in the inactivation of tumor suppressor genes in… (More)
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