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CpG Island Methylator Phenotype

Known as: CIMP, CIMP+ 
A phenotype whereby a subset of tumors are characterized by the simultaneous hypermethylation of multiple promoter-associated CpG islands.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Glioma CpG island methylator phenotype (G-CIMP): biological and clinical implications.
Gliomas are a heterogeneous group of brain tumors with distinct biological and clinical properties. Despite advances in surgical… 
Highly Cited
2014
Highly Cited
2014
A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype
Approximately 70% of KRAS-positive colorectal cancers (CRCs) have a CpG island methylator phenotype (CIMP) characterized by… 
Highly Cited
2013
Highly Cited
2013
Identification of a CpG island methylator phenotype in adrenocortical carcinomas.
PURPOSE DNA methylation is a mechanism for gene expression silencing in cancer. Limited information is available for… 
Highly Cited
2009
Highly Cited
2009
DNMT3B Expression Might Contribute to CpG Island Methylator Phenotype in Colorectal Cancer
Purpose: DNA methyltransferase-3B (DNMT3B) plays an important role in de novo CpG island methylation. Dnmt3b can induce colon… 
Highly Cited
2008
Highly Cited
2008
LINE‐1 hypomethylation is inversely associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer
The CpG island methylator phenotype (CIMP) with widespread promoter CpG island methylation is a phenotype in colorectal cancer… 
Highly Cited
2007
Highly Cited
2007
Diet and lifestyle factor associations with CpG island methylator phenotype and BRAF mutations in colon cancer
It has been proposed that dietary factors such as folate, alcohol and methionine may be associated with colon cancer because of… 
Highly Cited
2007
Highly Cited
2007
LINE-1 Hypomethylation in Cancer Is Highly Variable and Inversely Correlated with Microsatellite Instability
Background Alterations in DNA methylation in cancer include global hypomethylation and gene-specific hypermethylation. It is not… 
Highly Cited
2006
Highly Cited
2006
CpG island methylator phenotype (CIMP) of colorectal cancer is best characterised by quantitative DNA methylation analysis and prospective cohort studies
Background: The concept of CpG island methylator phenotype (CIMP) is not universally accepted. Even if specific… 
Highly Cited
2005
Highly Cited
2005
Prognostic significance of CpG island methylator phenotype and microsatellite instability in gastric carcinoma.
PURPOSE The influence of molecular characteristics in prognosis of gastric cancer remains unclear. The aim of this study was to… 
Highly Cited
2002
Highly Cited
2002
Characterisation of colorectal cancers showing hypermethylation at multiple CpG islands
Background and aims: A subgroup of colorectal cancers (CRC) referred to as the CpG island methylator phenotype (CIMP+) shows… 
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