CpG Island Methylator Phenotype

Known as: CIMP, CIMP+ 
A phenotype whereby a subset of tumors are characterized by the simultaneous hypermethylation of multiple promoter-associated CpG islands.
National Institutes of Health

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Highly Cited
2010
Highly Cited
2010
We have profiled promoter DNA methylation alterations in 272 glioblastoma tumors in the context of The Cancer Genome Atlas (TCGA… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND The CpG island methylator phenotype (CIMP), characterised by widespread promoter methylation, is associated with… (More)
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Highly Cited
2009
Highly Cited
2009
PURPOSE The CpG island methylator phenotype (CIMP) may be associated with development of malignancy through coordinated… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND & AIMS The CpG island methylator phenotype (CIMP) is one of the mechanisms involved in colorectal carcinogenesis (CRC… (More)
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Highly Cited
2007
Highly Cited
2007
It has been proposed that dietary factors such as folate, alcohol and methionine may be associated with colon cancer because of… (More)
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Highly Cited
2006
Highly Cited
2006
Aberrant DNA methylation of CpG islands has been widely observed in human colorectal tumors and is associated with gene silencing… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND Cigarette smoking has been associated with microsatellite instability in sporadic colon cancer. Most microsatellite… (More)
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Review
2004
Review
2004
DNA hypermethylation in CpG-rich promoters is now recognized as a common feature of human neoplasia. However, the pathophysiology… (More)
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Highly Cited
1999
Highly Cited
1999
Aberrant methylation of promoter region CpG islands is associated with transcriptional inactivation of tumor-suppressor genes in… (More)
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Highly Cited
1999
Highly Cited
1999
Aberrant methylation of 5' CpG islands is thought to play an important role in the inactivation of tumor suppressor genes in… (More)
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