Copy Number

The number of molecules of a particular type on or in a cell or part of a cell. Usually applied to specific genes or to plasmids within a bacterium… (More)
National Institutes of Health

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Highly Cited
2012
Highly Cited
2012
VarScan 2: somatic mutation and copy number alteration discovery in cancer by exome sequencing.
Cancer is a disease driven by genetic variation and mutation. Exome sequencing can be utilized for discovering these variants and… (More)
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Highly Cited
2011
Highly Cited
2011
Copy number variation and selection during reprogramming to pluripotency
The mechanisms underlying the low efficiency of reprogramming somatic cells into induced pluripotent stem (iPS) cells are poorly… (More)
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Highly Cited
2010
Highly Cited
2010
Allele-specific copy number analysis of tumors.
We present an allele-specific copy number analysis of the in vivo breast cancer genome. We describe a unique bioinformatics… (More)
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Highly Cited
2010
Highly Cited
2010
Functional impact of global rare copy number variation in autism spectrum disorders
The autism spectrum disorders (ASDs) are a group of conditions characterized by impairments in reciprocal social interaction and… (More)
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Highly Cited
2007
Highly Cited
2007
Relative impact of nucleotide and copy number variation on gene expression phenotypes.
Extensive studies are currently being performed to associate disease susceptibility with one form of genetic variation, namely… (More)
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Highly Cited
2005
Highly Cited
2005
A robust algorithm for copy number detection using high-density oligonucleotide single nucleotide polymorphism genotyping arrays.
We have developed a robust algorithm for copy number analysis of the human genome using high-density oligonucleotide microarrays… (More)
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Highly Cited
2005
Highly Cited
2005
Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study.
BACKGROUND The antiepidermal growth factor receptor (antiEGFR) monoclonal antibodies cetuximab and panitumumab have good clinical… (More)
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Highly Cited
2004
Highly Cited
2004
Circular binary segmentation for the analysis of array-based DNA copy number data.
DNA sequence copy number is the number of copies of DNA at a region of a genome. Cancer progression often involves alterations in… (More)
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Highly Cited
2001
Highly Cited
2001
Assembly of microarrays for genome-wide measurement of DNA copy number
We have assembled arrays of approximately 2,400 BAC clones for measurement of DNA copy number across the human genome. The arrays… (More)
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Highly Cited
2000
Highly Cited
2000
rRNA operon copy number reflects ecological strategies of bacteria.
Although natural selection appears to favor the elimination of gene redundancy in prokaryotes, multiple copies of each rRNA… (More)
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