Congenital hypoplasia of kidney

Congenital nephron number varies five-fold among normal humans, and individuals at the lower end of this range may have an… (More)

During kidney development and in response to inductive signals, the metanephric mesenchyme aggregates, becomes polarized, and… (More)

To bypass the essential gastrulation function of Fgf8 and study its role in lineages of the primitive streak, we have used a new… (More)

Reciprocal cell-cell interactions between the ureteric epithelium and the metanephric mesenchyme are needed to drive growth and… (More)

The murine Six gene family, homologous to Drosophila sine oculis (so) which encodes a homeodomain transcription factor, is… (More)

Mouse embryos deficient in Gata3 die by 11 days post coitum (d.p.c.) from pathology of undetermined origin. We recently showed… (More)

The murine genes, Foxc1 and Foxc2 (previously, Mf1 and Mfh1), encode forkhead/winged helix transcription factors with virtually… (More)

PAX2 mutations cause renal-coloboma syndrome (RCS), a rare multi-system developmental abnormality involving optic nerve colobomas… (More)

The Wilms' Tumour gene WT1 has important functions during development. Knock-out mice were shown to have defects in the… (More)

Paired box (PAX) genes play a critical role in human development and disease. The PAX2 gene is expressed in primitive cells of… (More)