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Complement component C6

Known as: Complement 6, Complement, C6, C6, Complement 
A 105-kDa serum glycoprotein with significant homology to the other late complement components, C7-C9. It is a polypeptide chain cross-linked by 32… Expand
National Institutes of Health

Related topics

Related topics

11 relations

Narrower (2)

C6 Deficiency, SubtotalComplement Component 6 Deficiency

Broader (2)

C6 geneImmunologic Factors
Process of secretionagonistsantagonists & inhibitorsaspects of radiation effects
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Papers overview

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Highly Cited
2012
Highly Cited
2012
Structure of Complement C6 Suggests a Mechanism for Initiation and Unidirectional, Sequential Assembly of Membrane Attack Complex (MAC)*♦
Background: The membrane attack complex (MAC) is an ancient component of immune defense that assembles lytic pores in pathogen… Expand
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2004
2004
Molecular basis for complement component 6 (C6) deficiency in rats and mice.
Complement component C6 is a part of the lytic membrane attack complex formed during complement activation. Animal modeling to… Expand
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1999
1999
Function of the factor I modules (FIMS) of human complement component C6.
In order to elucidate the function of complement component C6, truncated C6 molecules were expressed recombinantly. These were… Expand
1996
1996
Molecular bases for inherited human complement component C6 deficiency in two unrelated individuals.
Deficiency of the sixth component of complement (C6D) is frequently associated with recurrent neisserial infections, especially… Expand
1995
1995
DNA polymorphisms of the complement C6 and C7 genes
The linked C6 and C7 loci are rich in genetic markers, both at the protein and DNA levels. There are now seven common DNA… Expand
1993
1993
Polymorphism of human complement component C6: an amino acid substitution (Glu/Ala) within the second thrombospondin repeat differentiates between the two common allotypes C6 A and C6 B.
Component C6 of the human complement system exhibits a genetic polymorphism in all populations tested so far. Using isoelectric… Expand
Highly Cited
1989
Highly Cited
1989
Inhibition of acute passive transfer experimental autoimmune myasthenia gravis with Fab antibody to complement C6.
The role of the lytic complement C5b-9 membrane attack complex (MAC) in acute passive transfer experimental autoimmune myasthenia… Expand
Highly Cited
1989
Highly Cited
1989
The molecular architecture of human complement component C6.
The molecular architecture of human complement component C6 was elucidated at several levels of structural organization. The… Expand
Highly Cited
1989
Highly Cited
1989
Complete primary structure and functional characterization of the sixth component of the human complement system. Identification of the C5b-binding domain in complement C6.
Complement C6 is one of five plasma proteins that are incorporated into the lytic terminal complement complex on lipid membranes… Expand
1983
1983
POLYMORPHISM OF THE COMPLEMENT COMPONENT C6 IN JAPANESE
Genetic polymorphism of human C6 was investigated in Japanese using isoelectric focusing and a specific haemolytic overlay method… Expand
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