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Complement Membrane Attack Complex

Known as: Complement Sc5b-9, C5b-8-poly-C9, Membrane Attack Complex 
A product of COMPLEMENT ACTIVATION cascade, regardless of the pathways, that forms transmembrane channels causing disruption of the target CELL… 
National Institutes of Health

Related topics

Related topics

13 relations

Broader (2)

Complement System ProteinsImmunologic Factors
Complement component 9Immunologic CytotoxicityProcess of secretionagonists

Narrower (1)

SC5b-9 protein complex

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2003
Highly Cited
2003
Association Between Complement Factor H and Proteoglycans in Early Human Coronary Atherosclerotic Lesions: Implications for Local Regulation of Complement Activation
Objective—Complement activation has been suggested to play a role in atherogenesis. To study the regulation of complement… 
Highly Cited
2000
Highly Cited
2000
Acute vascular rejection is associated with systemic complement activation ina pig‐to‐primate kidney xenograft model
Abstract: The introduction of h‐DAF transgenic porcine organs into pre‐clinical pig‐to‐primate discordant xenotransplantation has… 
Highly Cited
2000
Highly Cited
2000
Resistance Against the Membrane Attack Complex of Complement Induced in Porcine Endothelial Cells with a Galα(1–3)Gal Binding Lectin: Up-Regulation of CD59 Expression1
Endothelial cells (EC) play central roles in vascular physiology and pathophysiology. EC activation results in proinflammatory… 
Highly Cited
1996
Highly Cited
1996
Evaluation of tissue trauma after laparoscopic and abdominal hysterectomy: measurements of neutrophil activation and release of interleukin-6, cortisol, and C-reactive protein.
BACKGROUND Trauma and major surgery stimulate a cascade of events that mediate the inflammatory response. The aim of our study… 
Highly Cited
1993
Highly Cited
1993
Terminal complement complex C5b-9 stimulates mitogenesis in 3T3 cells.
The membrane attack complex of complement (MAC) can induce reversible changes in cell membrane permeability resulting in… 
1988
1988
The complement membrane attack complex stimulates the prostanoid production of cultured glomerular epithelial cells.
Incubation of cultured rat glomerular epithelial cells (GEC) with sublytic amounts of the purified complement components C5b6, C7… 
Highly Cited
1988
Highly Cited
1988
Properdin, the terminal complement components, thrombospondin and the circumsporozoite protein of malaria parasites contain similar sequence motifs
Properdin is a plasma glycoprotein which stabilizes the C3bnBb¯ enzyme complex of the alternative pathway of the complement… 
Highly Cited
1986
Highly Cited
1986
Repolarization of the membrane potential of blood platelets after complement damage: evidence for a Ca++ -dependent exocytotic elimination of C5b-9 pores
Gel-filtered blood platelets exposed to complement proteins C5b-9 have previously been shown to undergo a reversible… 
Highly Cited
1985
Highly Cited
1985
Elimination of terminal complement intermediates from the plasma membrane of nucleated cells: the rate of disappearance differs for cells carrying C5b-7 or C5b-8 or a mixture of C5b-8 with a limited…
We have previously shown that multiple complement (C) channels are required for lysis of a nucleated cell in contrast to the… 
Highly Cited
1985
Highly Cited
1985
The membrane attack complex of complement: C5b-8 complex as accelerator of C9 polymerization.
Polymerization of C9 occurs spontaneously or can be induced by the tetramolecular complex C5b-8. Spontaneous C9 (0.15 mg/ml… 
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