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Complement Membrane Attack Complex

Known as: Complement Sc5b-9, C5b-8-poly-C9, Membrane Attack Complex 
A product of COMPLEMENT ACTIVATION cascade, regardless of the pathways, that forms transmembrane channels causing disruption of the target CELL… 
National Institutes of Health

Related topics

Related topics

13 relations

Broader (2)

Complement System ProteinsImmunologic Factors
Complement component 9Immunologic CytotoxicityProcess of secretionagonists

Narrower (1)

SC5b-9 protein complex

Papers overview

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1995
1995
Complement activation and release of tumour necrosis factor alpha, interleukin-2, interleukin-6 and soluble tumour necrosis factor and interleukin-2 receptors during and after cardiopulmonary bypass…
C3 activation products, terminal complement complex (TCC), and cytokines including interleukins 6 and 2 (IL-6, IL-2) and tumour… 
Highly Cited
1986
Highly Cited
1986
Complement activation in rheumatoid arthritis evaluated by C3dg and the terminal complement complex.
Complement activation was evaluated in plasma and synovial fluid from patients with rheumatoid arthritis. The activation fragment… 
1986
1986
Release of arachidonic acid and formation of oxygenated derivatives after complement attack on macrophages: role of channel formation.
Treatment of [3H]arachidonic acid ([3H]C20:4)-labeled, antibody-sensitized mouse resident peritoneal macrophages with rabbit… 
1986
1986
Assembly of the membrane attack complex of complement on small unilamellar phospholipid vesicles.
Light-scattering intensity was shown to be a reliable, direct, and quantitative technique for monitoring the assembly of the… 
Highly Cited
1985
Highly Cited
1985
Induction of prostanoid synthesis in human platelets by the late complement components C5b-9 and channel forming antibiotic nystatin: inhibition of the reacylation of liberated arachidonic acid.
Treatment of human platelets by the purified late complement components C5b-9 results in a dose- and time-dependent release of… 
Highly Cited
1983
Highly Cited
1983
Localization of the membrane attack complex (MAC) in experimental immune complex glomerulonephritis
The role of the membrane attack complex (MAC) as a mediator of renal tissue injury was evaluated in rats affected by bovine serum… 
1981
1981
Membrane attack complex of complement: distribution of subunits between the hydrocarbon phase of target membranes and water.
Membrane destruction by complement is effected by the membrane attack complex (MAC) which is the dimer of a fusion product of the… 
1981
1981
Effect of agents that produce membrane disorder on lysis of erythrocytes by complement.
To evaluate the effect of membrane lipid acyl-chain packing on the efficiency of cell lysis by complement, we have studied… 
1980
1980
The terminal membrane C5b-9 complex of human complement. Evidence for the existence of multiple protease-resistant polypeptides that form the trans-membrane complement channel.
C5b-9(m) complexes were incorporated into lecithin liposomes and subjected to proteolysis in the presence of DTT to remove the… 
1979
1979
Neoantigen of the complement membrane attack complex of cytotoxic human peripheral blood lymphocytes.
Neoantigenic determinants (neoAg) specific for the assembling membrane attack complex (MAC) of complement were detected by… 
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