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Complement Membrane Attack Complex

Known as: Complement Sc5b-9, C5b-8-poly-C9, Membrane Attack Complex 
A product of COMPLEMENT ACTIVATION cascade, regardless of the pathways, that forms transmembrane channels causing disruption of the target CELL… 
National Institutes of Health

Related topics

Related topics

13 relations

Broader (2)

Complement System ProteinsImmunologic Factors
Complement component 9Immunologic CytotoxicityProcess of secretionagonists

Narrower (1)

SC5b-9 protein complex

Papers overview

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Highly Cited
2003
Highly Cited
2003
Association Between Complement Factor H and Proteoglycans in Early Human Coronary Atherosclerotic Lesions: Implications for Local Regulation of Complement Activation
Objective—Complement activation has been suggested to play a role in atherogenesis. To study the regulation of complement… 
Highly Cited
2003
Highly Cited
2003
Complement activation in early protocol kidney graft biopsies after living-donor transplantation1
Background. To gain insight into complement activation in kidney grafts, we studied the deposition of components from all… 
Highly Cited
2000
Highly Cited
2000
Resistance Against the Membrane Attack Complex of Complement Induced in Porcine Endothelial Cells with a Galα(1–3)Gal Binding Lectin: Up-Regulation of CD59 Expression1
Endothelial cells (EC) play central roles in vascular physiology and pathophysiology. EC activation results in proinflammatory… 
Highly Cited
2000
Highly Cited
2000
Acute vascular rejection is associated with systemic complement activation ina pig‐to‐primate kidney xenograft model
Abstract: The introduction of h‐DAF transgenic porcine organs into pre‐clinical pig‐to‐primate discordant xenotransplantation has… 
Highly Cited
1995
Highly Cited
1995
Complement membrane attack complex, perforin, and bacterial exotoxins induce in K562 cells calcium-dependent cross-protection from lysis.
The complement membrane attack complex (MAC), the cytolytic granule protein of cytotoxic lymphocytes perforin, the streptococcal… 
Highly Cited
1994
Highly Cited
1994
Expression and function of the complement membrane attack complex inhibitor protectin (CD59) on human breast cancer cells.
BACKGROUND Normal human cells resist the lytic activity of homologous complement (C) by expressing inhibitory molecules on their… 
Highly Cited
1989
Highly Cited
1989
Complete primary structure and functional characterization of the sixth component of the human complement system. Identification of the C5b-binding domain in complement C6.
Complement C6 is one of five plasma proteins that are incorporated into the lytic terminal complement complex on lipid membranes… 
1988
1988
The complement membrane attack complex stimulates the prostanoid production of cultured glomerular epithelial cells.
Incubation of cultured rat glomerular epithelial cells (GEC) with sublytic amounts of the purified complement components C5b6, C7… 
Highly Cited
1986
Highly Cited
1986
Repolarization of the membrane potential of blood platelets after complement damage: evidence for a Ca++ -dependent exocytotic elimination of C5b-9 pores
Gel-filtered blood platelets exposed to complement proteins C5b-9 have previously been shown to undergo a reversible… 
Highly Cited
1985
Highly Cited
1985
Immunohistochemical studies of interleukin‐2 and γ‐interferon in rheumatoid arthritis
Synovial tissues were studied, using immunofluorescence techniques, for localization of lymphocytic infiltrates and immune… 
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