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Complement Membrane Attack Complex

Known as: Complement Sc5b-9, C5b-8-poly-C9, Membrane Attack Complex 
A product of COMPLEMENT ACTIVATION cascade, regardless of the pathways, that forms transmembrane channels causing disruption of the target CELL… 
National Institutes of Health

Related topics

Related topics

13 relations

Broader (2)

Complement System ProteinsImmunologic Factors
Complement component 9Immunologic CytotoxicityProcess of secretionagonists

Narrower (1)

SC5b-9 protein complex

Papers overview

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1986
1986
Does complement kill E. coli by producing transmural pores?
Three lines of evidence are presented to indicate that C5b-9 kills serum-sensitive E. coli K 12 cells by generating functional… 
1986
1986
Assembly of the membrane attack complex of complement on small unilamellar phospholipid vesicles.
Light-scattering intensity was shown to be a reliable, direct, and quantitative technique for monitoring the assembly of the… 
1986
1986
Immunohistochemical analysis of C3 cleavage fragments, factor H, and the C5b-9 terminal complex of complement in de novo membranous glomerulonephritis occurring in patients with renal transplant.
Fifteen renal biopsies from 13 transplanted patients with de novo membranous nephropathy (DNMN) were investigated by… 
Highly Cited
1985
Highly Cited
1985
Induction of prostanoid synthesis in human platelets by the late complement components C5b-9 and channel forming antibiotic nystatin: inhibition of the reacylation of liberated arachidonic acid.
Treatment of human platelets by the purified late complement components C5b-9 results in a dose- and time-dependent release of… 
Review
1985
Review
1985
Membrane damage by channel-forming proteins: staphylococcal alpha-toxin, streptolysin-O and the C5b-9 complement complex.
One mechanism through which cells can be damaged involves insertion of alien proteins into the membrane bilayer and the formation… 
1984
1984
Effect of erythrocyte membrane modulation by lysolecithin on complement-mediated lysis.
Alterations of the physiochemical properties of membranes, such as acyl chain length of phospholipids, cholesterol content, and… 
1984
1984
Complement protein C9 labeled with fluorescein isothiocyanate can be used to monitor C9 polymerization and formation of the cytolytic membrane lesion.
Human complement protein C9 was covalently labeled with the fluorescent chromophore fluorescein isothiocyanate (FITC) with only a… 
1984
1984
Species-restricted target cell lysis by human complement: complement-lysed erythrocytes from heterologous and homologous species differ in their ratio of bound to inserted C9.
The cytolytic efficiency of the terminal complement complex (C5b-9) against erythrocytes of different species is, in part… 
1981
1981
Effect of agents that produce membrane disorder on lysis of erythrocytes by complement.
To evaluate the effect of membrane lipid acyl-chain packing on the efficiency of cell lysis by complement, we have studied… 
1979
1979
Neoantigen of the complement membrane attack complex of cytotoxic human peripheral blood lymphocytes.
Neoantigenic determinants (neoAg) specific for the assembling membrane attack complex (MAC) of complement were detected by…