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Collagen Type II

Known as: Collagen Type II [Chemical/Ingredient], Type II collagen, Collagen, Type II 
A fibrillar collagen found predominantly in CARTILAGE and vitreous humor. It consists of three identical alpha1(II) chains.
National Institutes of Health

Related topics

Related topics

16 relations
COL2A1 geneHyaline CartilageIn BloodProcess of secretion

Narrower (4)

Collagen Type II, alpha1 SubunitProcollagen Type IIchondrocalcincollagen type II (108-116)

Broader (1)

Fibrillar Collagen

Papers overview

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Highly Cited
2006
Highly Cited
2006
Peptides of type II collagen can induce the cleavage of type II collagen and aggrecan in articular cartilage.
1999
1999
IFN-γ production in response to in vitro stimulation with collagen type II in rheumatoid arthritis is associated with HLA-DRB1*0401 and HLA-DQ8
IFN-γ was measured in supernatants after in vitro stimulation of peripheral blood mononuclear cells with collagen type II (CII… 
1996
1996
An alpha 1(II) Gly913 to Cys substitution prevents the matrix incorporation of type II collagen which is replaced with type I and III collagens in cartilage from a patient with hypochondrogenesis.
A heterozygous mutation in the COL2A1 gene was identified in a patient with hypochondrogenesis. The mutation was a single… 
Highly Cited
1995
Highly Cited
1995
Cartilage matrix protein forms a type II collagen-independent filamentous network: analysis in primary cell cultures with a retrovirus expression system.
Cartilage matrix protein (CMP) is expressed specifically in mature cartilage and consists of two von Willebrand factor A domains… 
1995
1995
Developmental expression of a type II collagen/β‐galactosidase fusion gene in transgenic mice
The correct temporal and spatial expression of the type II collagen gene is believed to be important for normal development and… 
1995
1995
Substitution of aspartic acid for glycine at position 310 in type II collagen produces achondrogenesis II, and substitution of serine at position 805 produces hypochondrogenesis: analysis of genotype…
Two different mutations were found in two unrelated probands with lethal chondrodysplasias, one with achondrogenesis type II and… 
1994
1994
Characterization of type II and type XI collagen synthesis by an immortalized rat chondrocyte cell line (IRC) having a low level of type II collagen mRNA expression.
The biosynthesis of type XI and type II collagens was examined using a stable rat chondrocyte cell line established by W. E… 
1991
1991
A limited association of generalized osteoarthritis with alleles at the type II collagen locus: COL2A1.
A significant genetic influence in osteoarthritis has been observed in the combination of Heberden's nodes and generalized… 
Highly Cited
1989
Highly Cited
1989
Independent deposition of collagen types II and IX at epithelial-mesenchymal interfaces.
Previous studies have demonstrated the presence of type II collagen (in mature chickens predominantly a 'cartilage-specific… 
1988
1988
Stimulation of interleukin‐1α and interleukin‐1β release from human monocytes by cyanogen bromide peptides of type ii collagen
Pyrogen-free cartilage fragments from patients with fracture, osteoarthritis, or rheumatoid arthritis were found to stimulate the… 
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