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Clopenthixol

Known as: 1-Piperazineethanol, 4-(3-(2-chloro-9H-thioxanthen-9-ylidene)propyl)-, CLOPENTHIXOL, TRANS, Clopenthixol [Chemical/Ingredient] 
A thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors.
National Institutes of Health

Related topics

Related topics

15 relations

Broader (2)

Antipsychotic AgentsDopamine Antagonists

Narrower (4)

CisordinolZuclopenthixolZuclopenthixol acetateclopenthixol decanoate
Clopenthixol:MCnc:Pt:Ser/Plas:QnClopenthixol:Mass:Pt:Dose:QnIn Bloodagonists
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Comparative efficacy and tolerability of 32 oral antipsychotics for the acute treatment of adults with multi-episode schizophrenia: a systematic review and network meta-analysis
Review
2017
Review
2017
Sixty Years of Placebo-Controlled Antipsychotic Drug Trials in Acute Schizophrenia: Systematic Review, Bayesian Meta-Analysis, and Meta-Regression of Efficacy Predictors.
OBJECTIVE Antipsychotic drug efficacy may have decreased over recent decades. The authors present a meta-analysis of all placebo… 
Review
2013
Review
2013
Withdrawal versus continuation of chronic antipsychotic drugs for behavioural and psychological symptoms in older people with dementia.
BACKGROUND Antipsychotic agents are often used to treat neuropsychiatric symptoms (NPS) in dementia, although the literature is… 
Review
2013
Review
2013
Efficacy and effectiveness of depot versus oral antipsychotics in schizophrenia: synthesizing results across different research designs.
OBJECTIVE Nonadherence is a major challenge in schizophrenia treatment. While long-acting (depot) antipsychotic medications are… 
Review
2007
Review
2007
Reversal of resistance in microorganisms by help of non-antibiotics.
Intracellular efflux pumps have been largely the research focus in multidrug-resistant (MDR) Gram-positive and Gram-negative… 
Highly Cited
2002
Highly Cited
2002
Separation of cis- and trans-isomers of thioxanthene and dibenz[b,e]oxepin derivatives on calixarene- and resorcinarene-bonded high-performance liquid chromatography stationary phases.
1994
1994
QEEG alpha1 changes after a single dose of high-potency neuroleptics as a predictor of short-term response to treatment in schizophrenic patients
1993
1993
Serotonergic aspects of acute extrapyramidal syndromes in nonhuman primates
  • D. Casey
  • Schizophrenia Research
  • 1993
  • Corpus ID: 44949443
1981
1981
Binding of [3H]sulpiride to purified rat striatal synaptic membranes
Highly Cited
1973
Highly Cited
1973
The comparative pharmacology of flupenthixol and some reference neuroleptics.
: Flupenthixol, a thioxanthene derivative may exist in two isomeric forms, α and β. Flupenthixol contains 45-55 % α-flupenthixol… 
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