Clonal Expansion

Multiplication or reproduction by cell division of a population of identical cells descended from a single progenitor. In immunology, may refer to… (More)
National Institutes of Health

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Highly Cited
2014
Highly Cited
2014
Several genetic alterations characteristic of leukemia and lymphoma have been detected in the blood of individuals without… (More)
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Highly Cited
2011
Highly Cited
2011
There is emerging evidence that people with successfully treated HIV infection age prematurely, leading to progressive multi… (More)
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Highly Cited
2009
Highly Cited
2009
Cancers are clonal expansions, but how a single, transformed human cell grows into a billion-cell tumor is uncertain because… (More)
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Highly Cited
2008
Highly Cited
2008
Emerging and re-emerging infectious diseases, especially those caused by drug-resistant bacteria, are a major problem worldwide… (More)
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Highly Cited
2003
Highly Cited
2003
We have analyzed 11,500 isolates of Mycobacterium bovis (the cause of tuberculosis in cattle and other mammals) isolated in Great… (More)
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Highly Cited
2001
Highly Cited
2001
Human tissues acquire somatic mitochondrial DNA (mtDNA) mutations with age. Very high levels of specific mtDNA mutations… (More)
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Highly Cited
2000
Highly Cited
2000
Evidence is presented that calpain, a calcium-activated protease, degrades the cyclin-dependent kinase inhibitor, p27, during the… (More)
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Highly Cited
2000
Highly Cited
2000
The biochemical mechanisms involved in regulation of insulin secretion are not completely understood. The rat INS-1 cell line has… (More)
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Highly Cited
1999
Highly Cited
1999
Splenic marginal-zone B cells, marginal-zone B cells of Peyer's patches in the gut, and nodal marginal-zone B cells (also… (More)
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Highly Cited
1992
Highly Cited
1992
The genesis of human follicular lymphoma (FL) is a multistep process. The initial event is thought to be the chromosomal… (More)
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