Chromosomes, Artificial, Human

Known as: Human Artificial Chromosomes, Chromosome, Human Artificial, HAC (Chromosome) 
DNA constructs that are composed of, at least, all elements, such as a REPLICATION ORIGIN; TELOMERE; and CENTROMERE, required for successful… (More)

Topic mentions per year

Topic mentions per year

1999-2018
02419992018

Papers overview

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2014
2014
In human chromosomes, centromeric regions comprise megabase-size arrays of 171 bp alpha-satellite DNA monomers. The large… (More)
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2011
2011
Human artificial chromosomes (HACs) have unique characteristics as gene-delivery vectors, including episomal transmission and… (More)
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2011
2011
Human artificial chromosome (HAC)-based vectors offer a promising system for delivery and expression of full-length human genes… (More)
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2010
2010
Human artificial chromosomes (HACs), which carry a fully functional centromere and are maintained as a single-copy episome, are… (More)
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2008
2008
Human artificial chromosomes (HACs) have several advantages as gene therapy vectors, including stable episomal maintenance that… (More)
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2005
2005
Human artificial chromosomes (HACs) segregating freely from host chromosomes are potentially useful to ensure both safety and… (More)
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2005
2005
Alpha-satellite (alphoid) DNA is necessary for de novo formation of human artificial chromosomes (HACs) in human cultured cells… (More)
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2002
2002
BACKGROUND Human artificial chromosomes (HACs) are generated from the precursor DNA constructs containing alpha-satellite DNA… (More)
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Highly Cited
2002
Highly Cited
2002
Human polyclonal antibodies (hPABs) are useful therapeutics, but because they are available only from human donors, their supply… (More)
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1999
1999
A human artificial chromosome (HAC) vector was constructed from a 1-Mb yeast artificial chromosome (YAC) that was selected based… (More)
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