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Chromosomes, Artificial, Human

Known as: Human Artificial Chromosomes, Chromosome, Human Artificial, HAC (Chromosome) 
DNA constructs that are composed of, at least, all elements, such as a REPLICATION ORIGIN; TELOMERE; and CENTROMERE, required for successful… 
National Institutes of Health

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4 relations
MicrobiologicalProcess of secretionaspects of radiation effectsphysiological aspects

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
Integration-Free iPS Cells Engineered Using Human Artificial Chromosome Vectors
Human artificial chromosomes (HACs) have unique characteristics as gene-delivery vectors, including episomal transmission and… 
2010
2010
A gene delivery system with a human artificial chromosome vector based on migration of mesenchymal stem cells towards human glioblastoma HTB14 cells
Abstract Mesenchymal stem cells (MSCs) have been expected to become useful gene delivery vehicles against human malignant gliomas… 
2008
2008
Correction of a genetic defect in multipotent germline stem cells using a human artificial chromosome
Human artificial chromosomes (HACs) have several advantages as gene therapy vectors, including stable episomal maintenance that… 
Highly Cited
2006
Highly Cited
2006
Human Artificial Chromosomes Constructed Using the Bottom-up Strategy Are Stably Maintained in Mitosis and Efficiently Transmissible to Progeny Mice*
Human artificial chromosomes (HACs) are alternative vectors that promise to overcome problematic transgene expression often… 
2006
2006
Exogenous gene expression and growth regulation of hematopoietic cells via a novel human artificial chromosome
AbstractA number of gene delivery systems are currently being developed for potential use in gene therapy. Here, we demonstrate… 
2005
2005
A Novel Human Artificial Chromosome Vector Provides Effective Cell Lineage–Specific Transgene Expression in Human Mesenchymal Stem Cells
Mesenchymal stem cells (MSCs) hold promise for use in adult stem cell–mediated gene therapy. One of the major aims of stem cell… 
Highly Cited
2005
Highly Cited
2005
Human artificial chromosome (HAC) vector provides long-term therapeutic transgene expression in normal human primary fibroblasts
Human artificial chromosomes (HACs) segregating freely from host chromosomes are potentially useful to ensure both safety and… 
Review
2005
Review
2005
Artificial and engineered chromosomes: developments and prospects for gene therapy
At the gene therapy session of the ICCXV Chromosome Conference (2004), recent advances in the construction of engineered… 
2005
2005
A novel expression system for genomic DNA loci using a human artificial chromosome vector with transformation-associated recombination cloning
AbstractFollowing the recent completion of the human genome sequence, genomics research has shifted its focus to understanding… 
1995
1995
Effect of hepatic artery chemotherapy on survival of patients with hepatic metastases from colorectal carcinoma treated with cryotherapy
Thirty-eight patients with unresectable multiple liver metastases from colorectal carcinoma were treated with either hepatic… 
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