Skip to search formSkip to main contentSkip to account menu

Chromosomes, Artificial, Human

Known as: Human Artificial Chromosomes, Chromosome, Human Artificial, HAC (Chromosome) 
DNA constructs that are composed of, at least, all elements, such as a REPLICATION ORIGIN; TELOMERE; and CENTROMERE, required for successful… 
National Institutes of Health

Related topics

Related topics

4 relations
MicrobiologicalProcess of secretionaspects of radiation effectsphysiological aspects

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Refined human artificial chromosome vectors for gene therapy and animal transgenesis
Human artificial chromosomes (HACs) have several advantages as gene therapy vectors, including stable episomal maintenance, and… 
Highly Cited
2010
Highly Cited
2010
Comparative analysis of transcriptional and physiological responses of Bacillus cereus to organic and inorganic acid shocks.
Highly Cited
2006
Highly Cited
2006
A novel human artificial chromosome gene expression system using herpes simplex virus type 1 vectors
Human artificial chromosome (HAC) vectors are an important gene transfer system for expression and complementation studies. We… 
2005
2005
A Novel Human Artificial Chromosome Vector Provides Effective Cell Lineage–Specific Transgene Expression in Human Mesenchymal Stem Cells
Mesenchymal stem cells (MSCs) hold promise for use in adult stem cell–mediated gene therapy. One of the major aims of stem cell… 
Highly Cited
2003
Highly Cited
2003
Cloning of human centromeres by transformation-associated recombination in yeast and generation of functional human artificial chromosomes.
Human centromeres remain poorly characterized regions of the human genome despite their importance for the maintenance of… 
Highly Cited
2002
Highly Cited
2002
Efficiency of de novo centromere formation in human artificial chromosomes.
In a comparative study, we show that human artificial chromosome (HAC) vectors based on alpha-satellite (alphoid) DNA from… 
Highly Cited
2002
Highly Cited
2002
Alpha-satellite DNA and vector composition influence rates of human artificial chromosome formation.
Human artificial chromosomes (HACs) have been proposed as a new class of potential gene transfer and gene therapy vector. HACs… 
Highly Cited
2001
Highly Cited
2001
Functional complementation of a genetic deficiency with human artificial chromosomes.
We have shown functional complementation of a genetic deficiency in human cultured cells, using artificial chromosomes derived… 
Highly Cited
1999
Highly Cited
1999
Human artificial chromosomes generated by modification of a yeast artificial chromosome containing both human alpha satellite and single-copy DNA sequences.
A human artificial chromosome (HAC) vector was constructed from a 1-Mb yeast artificial chromosome (YAC) that was selected based… 
Highly Cited
1998
Highly Cited
1998
Assay of centromere function using a human artificial chromosome
Abstract. In order to define a functional human centromere sequence, an artificial chromosome was constructed as a reproducible… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)