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Chromosome 17 Centromere Probe

Known as: CEN17, Centromere 17, CEN-17 
A DNA probe designed for in situ hybridization. This probe is complementary to DNA sequences found in the centromeric region of chromosome 17. This… Expand
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
HER2 Gene Amplification Testing by Fluorescent In Situ Hybridization (FISH): Comparison of the ASCO-College of American Pathologists Guidelines With FISH Scores Used for Enrollment in Breast Cancer…
Purpose ASCO and the College of American Pathologists (ASCO-CAP) recently recommended further changes to the evaluation of human… Expand
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Highly Cited
2009
Highly Cited
2009
Does chromosome 17 centromere copy number predict polysomy in breast cancer? A fluorescence in situ hybridization and microarray‐based CGH analysis
Approximately 8% of breast cancers show increased copy numbers of chromosome 17 centromere (CEP17) by fluorescence in situ… Expand
Highly Cited
2009
Highly Cited
2009
Absence of chromosome 17 polysomy in breast cancer: analysis by CEP17 chromogenic in situ hybridization and multiplex ligation-dependent probe amplification
Amplification of the HER2 gene, present in 15–30% of breast carcinomas, correlates with poor outcome and is an indication for… Expand
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2009
2009
Prediction of HER2 gene status in Her2 2+ invasive breast cancer: a study of 108 cases comparing ASCO/CAP and FDA recommendations
Most Her2 testing guidelines recommend that all cases scoring Her2 2+ by immunohistochemistry should be analyzed by fluorescent… Expand
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Review
2008
Review
2008
Development of automated brightfield double In Situ hybridization (BDISH) application for HER2 gene and chromosome 17 centromere (CEN 17) for breast carcinomas and an assay performance comparison to…
BackgroundHuman epidermal growth factor receptor 2 (HER2) fluorescence in situ hybridization (FISH) is a quantitative assay for… Expand
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Highly Cited
2008
Highly Cited
2008
Evaluation of gene amplification and protein expression of HER-2/neu in esophageal squamous cell carcinoma using Fluorescence in situ Hybridization (FISH) and immunohistochemistry
BackgroundEsophageal squamous cell carcinoma (ESCC) is the sixth most frequent neoplasia in Brazil. It is usually associated with… Expand
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Highly Cited
2005
Highly Cited
2005
Polysomy 17 in HER-2/neu Status Elaboration in Breast Cancer: Effect on Daily Practice
Purpose: To assess the effect of chromosome 17 copy number on HER-2/neu status determination in breast cancers. Experimental… Expand
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Highly Cited
2002
Highly Cited
2002
Molecular-cytogenetic analysis of HER-2/neu gene in BRCA1-associated breast cancers.
The BRCA1 tumor suppressor gene and the HER-2/neu oncogene are located in close proximity on the long arm of chromosome 17 (17q11… Expand
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Highly Cited
2000
Highly Cited
2000
Amplification and deletion of topoisomerase IIalpha associate with ErbB-2 amplification and affect sensitivity to topoisomerase II inhibitor doxorubicin in breast cancer.
Topoisomerase IIalpha (topoIIalpha) is a key enzyme in DNA replication and a molecular target for many anti-cancer drugs called… Expand
Highly Cited
1999
Highly Cited
1999
c-myc and chromosome 8 centromere studies of ovarian cancer by interphase FISH.
Forty tumor specimens from patients with ovarian cancer were studied for amplification of the c-myc oncogene relative to… Expand
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