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Chromosome 17 Centromere Probe

Known as: CEN17, Centromere 17, CEN-17 
A DNA probe designed for in situ hybridization. This probe is complementary to DNA sequences found in the centromeric region of chromosome 17. This… Expand
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Predictive markers of anthracycline benefit: a prospectively planned analysis of the UK National Epirubicin Adjuvant Trial (NEAT/BR9601).
BACKGROUND The NEAT/BR9601 trial showed benefit for addition of anthracyclines to cyclophosphamide, methotrexate, and… Expand
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Highly Cited
2009
Highly Cited
2009
Does chromosome 17 centromere copy number predict polysomy in breast cancer? A fluorescence in situ hybridization and microarray-based CGH analysis.
Approximately 8% of breast cancers show increased copy numbers of chromosome 17 centromere (CEP17) by fluorescence in situ… Expand
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Highly Cited
2009
Highly Cited
2009
Absence of chromosome 17 polysomy in breast cancer: analysis by CEP17 chromogenic in situ hybridization and multiplex ligation-dependent probe amplification
Amplification of the HER2 gene, present in 15–30% of breast carcinomas, correlates with poor outcome and is an indication for… Expand
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2006
2006
Evaluation of Her-2/neu status in carcinomas with amplified chromosome 17 centromere locus.
Accurate assessment of Her-2/neu (erb-b2) status in breast carcinoma is essential for therapy planning. Clinical assays are… Expand
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2006
2006
Search on chromosome 17 centromere reveals TNFRSF13B as a susceptibility gene for intracranial aneurysm: a preliminary study.
BACKGROUND Our previous studies have shown a significant linkage of intracranial aneurysms (IAs) to chromosome 17. METHODS AND… Expand
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2006
2006
Prognostic value of HER2 expression in meningiomas: an immunohistochemical and fluorescence in situ hybridization study.
The aggressiveness of meningiomas is unpredictable. HER2 represents a well-known prognostic factor in various tumors such as… Expand
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Highly Cited
2005
Highly Cited
2005
Polysomy 17 in HER-2/neu Status Elaboration in Breast Cancer: Effect on Daily Practice
Purpose: To assess the effect of chromosome 17 copy number on HER-2/neu status determination in breast cancers. Experimental… Expand
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Highly Cited
2002
Highly Cited
2002
HER2 testing in patients with breast cancer: poor correlation between weak positivity by immunohistochemistry and gene amplification by fluorescence in situ hybridization.
OBJECTIVE To evaluate amplification of the HER-2/neu gene by fluorescence ir situ hybridization (FISH) in tumors with weakly… Expand
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Highly Cited
2000
Highly Cited
2000
Amplification and deletion of topoisomerase IIalpha associate with ErbB-2 amplification and affect sensitivity to topoisomerase II inhibitor doxorubicin in breast cancer.
Topoisomerase IIalpha (topoIIalpha) is a key enzyme in DNA replication and a molecular target for many anti-cancer drugs called… Expand
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1999
1999
c-myc and chromosome 8 centromere studies of ovarian cancer by interphase FISH.
Forty tumor specimens from patients with ovarian cancer were studied for amplification of the c-myc oncogene relative to… Expand
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