Chromosome 17 Centromere Probe
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Purpose ASCO and the College of American Pathologists (ASCO-CAP) recently recommended further changes to the evaluation of human… Expand Approximately 8% of breast cancers show increased copy numbers of chromosome 17 centromere (CEP17) by fluorescence in situ… Expand Amplification of the HER2 gene, present in 15–30% of breast carcinomas, correlates with poor outcome and is an indication for… Expand Most Her2 testing guidelines recommend that all cases scoring Her2 2+ by immunohistochemistry should be analyzed by fluorescent… Expand BackgroundHuman epidermal growth factor receptor 2 (HER2) fluorescence in situ hybridization (FISH) is a quantitative assay for… Expand BackgroundEsophageal squamous cell carcinoma (ESCC) is the sixth most frequent neoplasia in Brazil. It is usually associated with… Expand Purpose: To assess the effect of chromosome 17 copy number on HER-2/neu status determination in breast cancers. Experimental… Expand The BRCA1 tumor suppressor gene and the HER-2/neu oncogene are located in close proximity on the long arm of chromosome 17 (17q11… Expand Topoisomerase IIalpha (topoIIalpha) is a key enzyme in DNA replication and a molecular target for many anti-cancer drugs called… Expand Forty tumor specimens from patients with ovarian cancer were studied for amplification of the c-myc oncogene relative to… Expand