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Cf 1743

Known as: Cf-1743, Cf1743 
 
National Institutes of Health

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Pyrimidine Nucleosides

Papers overview

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2011
2011
Pharmacokinetics and safety of FV-100, a novel oral anti-herpes zoster nucleoside analogue, administered in single and multiple doses to healthy young adult and elderly adult volunteers.
FV-100 is the prodrug of the highly potent anti-varicella zoster virus bicyclic nucleoside analogue CF-1743. To characterize the… Expand
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Review
2010
Review
2010
FV-100: The Most Potent and Selective Anti-Varicella Zoster Virus Agent Reported to Date
Bicyclic aryl furano pyrimidines represent the most potent anti-varicella zoster virus (VZV) agents reported to date. Lead… Expand
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2010
2010
Evaluation of Novel Phosphoramidate ProTides of the 2′-Fluoro Derivatives of a Potent Anti-Varicella Zoster Virus Bicyclic Nucleoside Analogue
Background: Recently, the synthesis and antiviral activity of a series of 2′-fluoro derivatives of the most potent anti-varicella… Expand
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Review
2009
Review
2009
FV100 as a new approach for the possible treatment of varicella-zoster virus infection.
FV100 is a promising new agent with extreme potency and specificity for varicella-zoster virus (VZV). It is the valyl ester pro… Expand
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2009
2009
A Study of the Safety and Pharmacokinetics of Multiple Ascending Doses of FV-100 in Healthy Subjects
Twenty-two of 42 subjects reported at least 1 AEs (Table 2); 23 were thought by the Investigator to be possibly related to study… Expand
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2007
2007
Preclinical development of bicyclic nucleoside analogues as potent and selective inhibitors of varicella zoster virus.
OBJECTIVES To progress the anti-varicella-zoster-virus (VZV) aryl bicyclic nucleoside analogues (BCNAs) to the point of Phase 1… Expand
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