Skip to search formSkip to main contentSkip to account menu

Central Tolerance

Known as: Tolerance, Central 
The mechanism, in central lymphoid organs (THYMUS; BONE MARROW), that prevents immature lymphocytes from reacting to SELF-ANTIGENS. This is… 
National Institutes of Health

Related topics

Related topics

2 relations
aspects of radiation effectsphysiological aspects

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
Crosspresentation by nonhematopoietic and direct presentation by hematopoietic cells induce central tolerance to myelin basic protein
Central tolerance plays a critical role in eliminating self-reactive T cells specific for peripheral antigens. Here we show that… 
Review
2007
Review
2007
The role of B cells in the induction of peripheral T cell tolerance
The immune system of vertebrates is designed to protect against invading pathogens. To be able to deal with different antigenic… 
2007
2007
Opioids and efflux transporters. Part 1: P-glycoprotein substrate activity of N-substituted analogs of meperidine.
Review
2006
Review
2006
Induction of transplantation tolerance via regulatory T cells.
In the last two decades, graft survival has been greatly improved by the introduction of efficient immunosuppressive drugs. On… 
Review
2005
Review
2005
Advances in strategies for inducing central tolerance in organ allograft recipients
Abstract:  Encouraging results in large animal models and from the clinic have been reported recently suggesting that the… 
2005
2005
Induction of central T cell tolerance: Recombinant antibodies deliver peptides for deletion of antigen‐specific CD4+8+ thymocytes
In order to prevent or ameliorate autoimmune disease, it would be desirable to induce central tolerance to peripheral self… 
2003
2003
Autoreactive T cells can be protected from tolerance induction through competition by flanking determinants for access to class II MHC
It is not clear why the N-terminal autoantigenic determinant of myelin basic protein (MBP), Ac1–9, is dominant in the B1O.PL (H… 
Highly Cited
2001
Highly Cited
2001
The Goodpasture antigen is expressed in the human thymus.
BACKGROUND Autoimmunity to kidney antigens causes membranous nephropathy and Goodpasture's disease and very likely is pivotal in… 
Review
1999
Review
1999
Toward tolerance: lessons learned from liver transplantation.
*Define the various concepts of transplantation tolerance: Immunologically: unresponsiveness to donor antigens Clinically… 
1982
1982
Mechanisms Involved in Age‐dependent Decline of Immune Responsiveness and Apparent Resistance against Tolerance Induction in C57BL/6 Mice
The plaque‐forming antibody response of C57BL/6 mice to rabbit gamma globulin (RGG) decreases as a function of age. RGG in… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)