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Central Tolerance

Known as: Tolerance, Central 
The mechanism, in central lymphoid organs (THYMUS; BONE MARROW), that prevents immature lymphocytes from reacting to SELF-ANTIGENS. This is… 
National Institutes of Health

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aspects of radiation effectsphysiological aspects

Papers overview

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Review
2013
Review
2013
Alterations of the autoimmune regulator transcription factor and failure of central tolerance: APECED as a model
Self–nonself discrimination plays a key role in inducing a productive immunity and in preventing autoimmune reactions. Central… 
2010
2010
A new site-directed transgenic rheumatoid factor mouse model demonstrates extrafollicular class switch and plasmablast formation
The AM14 rheumatoid factor (RF) transgenic (Tg) mouse has been valuable for studying how self-reactive B cells are regulated… 
2008
2008
Crosspresentation by nonhematopoietic and direct presentation by hematopoietic cells induce central tolerance to myelin basic protein
Central tolerance plays a critical role in eliminating self-reactive T cells specific for peripheral antigens. Here we show that… 
Review
2007
Review
2007
The role of B cells in the induction of peripheral T cell tolerance
The immune system of vertebrates is designed to protect against invading pathogens. To be able to deal with different antigenic… 
2007
2007
Opioids and efflux transporters. Part 1: P-glycoprotein substrate activity of N-substituted analogs of meperidine.
2006
2006
Antibody-Induced Transplantation Tolerance That Is Dependent on Thymus-Derived Regulatory T Cells1
Targeting of the CD45RB isoform by mAb (anti-CD45RB) effectively induces donor-specific tolerance to allografts. The… 
2003
2003
Autoreactive T cells can be protected from tolerance induction through competition by flanking determinants for access to class II MHC
It is not clear why the N-terminal autoantigenic determinant of myelin basic protein (MBP), Ac1–9, is dominant in the B1O.PL (H… 
2003
2003
Knowing one's self: central tolerance revisited
Tissue-specific antigens are expressed in the thymic medulla under the influence of the AIRE gene, suggesting that… 
Highly Cited
2001
Highly Cited
2001
The Goodpasture antigen is expressed in the human thymus.
BACKGROUND Autoimmunity to kidney antigens causes membranous nephropathy and Goodpasture's disease and very likely is pivotal in… 
Review
1995
Review
1995
Central tolerance of T cells.
The immune system is constructed to tolerate self antigens but give vigorous responses to foreign antigens. How this state of… 
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