Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

Central Tolerance

Known as: Tolerance, Central 
The mechanism, in central lymphoid organs (THYMUS; BONE MARROW), that prevents immature lymphocytes from reacting to SELF-ANTIGENS. This is… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Central tolerance can be mediated by peripheral dendritic cells (DCs) that transport innocuous antigens (Ags) to the thymus for… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2010
Highly Cited
2010
Medullary thymic epithelial cells (mTECs) serve an essential function in central tolerance by expressing peripheral-tissue… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2007
Highly Cited
2007
The intestinal epithelium functions to absorb nutrients and to protect the organism against microbes. To prevent autoimmune… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2006
Highly Cited
2006
Immature CD4+CD8+ thymocytes, which are generated in the thymic cortex, are induced upon positive selection to differentiate into… Expand
Is this relevant?
Highly Cited
2006
Highly Cited
2006
A healthy individual can mount an immune response to exogenous pathogens while avoiding an autoimmune attack on normal tissues… Expand
  • figure 1
  • figure 2
  • table 1
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Intrathymic expression of tissue-specific antigens (TSAs) by medullary thymic epithelial cells (Mtecs) leads to deletion of… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Review
2004
Review
2004
The establishment and maintenance of immunological tolerance entails both central and peripheral mechanisms. The latter have been… Expand
Is this relevant?
Highly Cited
2003
Highly Cited
2003
Thymocytes depend on the interaction with thymic epithelial cells for the generation of a diverse, nonautoreactive T cell… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Review
2003
Review
2003
Dendritic cells (DCs) are uniquely well-equipped antigen-presenting cells (APCs) regarded classically as sentinels of the immune… Expand
Is this relevant?
Highly Cited
1995
Highly Cited
1995
The immunodominant epitope of myelin basic protein, Ac1-9, is encephalitogenic in H-2u mice. We have previously demonstrated that… Expand
Is this relevant?