Central Tolerance

Known as: Tolerance, Central 
The mechanism, in central lymphoid organs (THYMUS; BONE MARROW), that prevents immature lymphocytes from reacting to SELF-ANTIGENS. This is… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2004-2017
0520042017

Papers overview

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2016
2016
B cells are unique antigen-presenting cells because their antigen presentation machinery is closely tied to the B cell receptor… (More)
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2016
2016
OBJECTIVES To assess the prerequisites for negative selection of peptidylcitrulline-specific T cells in the thymus. In detail, we… (More)
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2015
2015
BACKGROUND & AIMS Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) is an autoimmune disorder characterized… (More)
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Review
2015
Review
2015
Dendritic cells (DCs) play a significant role in establishing self-tolerance through their ability to present self-antigens to… (More)
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2014
2014
Medullary thymic epithelial cells (mTECs) facilitate the deletion of developing self-reactive T cells by displaying a diverse… (More)
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2014
2014
Immunity to tumor differentiation antigens, such as melanoma antigen recognized by T cells 1 (MART-1), has been comprehensively… (More)
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2014
2014
In chronic viral infections, persistent antigen presentation causes progressive exhaustion of virus-specific CD8+ T cells. It has… (More)
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2013
2013
UNLABELLED The thymus is the organ in which T lymphocytes mature. Thymocytes undergo exhaustive selection processes that require… (More)
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2011
2011
According to the "two-step model," the intrathymic generation of CD4⁺ regulatory T (T(reg)) cells segregates into a first, T cell… (More)
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Highly Cited
2004
Highly Cited
2004
Intrathymic expression of tissue-specific antigens (TSAs) by medullary thymic epithelial cells (Mtecs) leads to deletion of… (More)
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