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Castration

Known as: Castrations, Surgical Castration, castration surgical 
Surgical removal of the testicles (orchiectomy) or ovaries (oophorectomy) to stop the production of sex hormones. Decreasing the levels of hormones… 
National Institutes of Health

Papers overview

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Highly Cited
2017
Highly Cited
2017
Background Abiraterone acetate, a drug that blocks endogenous androgen synthesis, plus prednisone is indicated for metastatic… 
Highly Cited
2016
Highly Cited
2016
An increasingly recognized resistance mechanism to androgen receptor (AR)-directed therapy in prostate cancer involves epithelial… 
Highly Cited
2010
Highly Cited
2010
BACKGROUND Sipuleucel-T, an autologous active cellular immunotherapy, has shown evidence of efficacy in reducing the risk of… 
Highly Cited
2008
Highly Cited
2008
Purpose: A method for enumerating circulating tumor cells (CTC) has received regulatory clearance. The primary objective of this… 
Highly Cited
2008
Highly Cited
2008
Therapy for advanced prostate cancer centers on suppressing systemic androgens and blocking activation of the androgen receptor… 
Highly Cited
2008
Highly Cited
2008
Although systemic androgen deprivation prolongs life in advanced prostate cancer, remissions are temporary because patients… 
Review
2005
Review
2005
  • H. Scher, C. Sawyers
  • Journal of clinical oncology : official journal…
  • 2005
  • Corpus ID: 31869697
Prostate cancers that are progressing on medical and surgical therapies designed to ablate the action of androgens continue to… 
Highly Cited
1972
Highly Cited
1972
Carcinoma of the prostate gland is peculiarly favorable for endocrine investigation since frequent serial observations of the… 
Highly Cited
1941
Highly Cited
1941
The thesis of this work may be briefly summarized. In many instances a malignant prostatic tumor is an overgrowth of adult…