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Castration

Known as: Castrations, Surgical Castration, castration surgical 
Surgical removal of the testicles (orchiectomy) or ovaries (oophorectomy) to stop the production of sex hormones. Decreasing the levels of hormones… 
National Institutes of Health

Related topics

Related topics

16 relations
Educational aspectsEndocrine systemEunuchismGenitourinary system
Expand

Broader (4)

Endocrine Surgical ProceduresExcisionReproductive systemSexual sterilization

Narrower (1)

Male Castration

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
Abiraterone plus Prednisone in Metastatic, Castration‐Sensitive Prostate Cancer
Background Abiraterone acetate, a drug that blocks endogenous androgen synthesis, plus prednisone is indicated for metastatic… 
Highly Cited
2016
Highly Cited
2016
Divergent clonal evolution of castration resistant neuroendocrine prostate cancer
An increasingly recognized resistance mechanism to androgen receptor (AR)-directed therapy in prostate cancer involves epithelial… 
Highly Cited
2010
Highly Cited
2010
Sipuleucel-T immunotherapy for castration-resistant prostate cancer.
BACKGROUND Sipuleucel-T, an autologous active cellular immunotherapy, has shown evidence of efficacy in reducing the risk of… 
Highly Cited
2010
Highly Cited
2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial
Highly Cited
2008
Highly Cited
2008
Circulating Tumor Cells Predict Survival Benefit from Treatment in Metastatic Castration-Resistant Prostate Cancer
Purpose: A method for enumerating circulating tumor cells (CTC) has received regulatory clearance. The primary objective of this… 
Highly Cited
2008
Highly Cited
2008
Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth.
Therapy for advanced prostate cancer centers on suppressing systemic androgens and blocking activation of the androgen receptor… 
Highly Cited
2008
Highly Cited
2008
Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer.
Although systemic androgen deprivation prolongs life in advanced prostate cancer, remissions are temporary because patients… 
Review
2005
Review
2005
Biology of progressive, castration-resistant prostate cancer: directed therapies targeting the androgen-receptor signaling axis.
  • H. Scher, C. Sawyers
  • Journal of clinical oncology : official journal…
  • 2005
  • Corpus ID: 31869697
Prostate cancers that are progressing on medical and surgical therapies designed to ablate the action of androgens continue to… 
Highly Cited
1972
Highly Cited
1972
Studies on prostatic cancer: I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate
Carcinoma of the prostate gland is peculiarly favorable for endocrine investigation since frequent serial observations of the… 
Highly Cited
1941
Highly Cited
1941
STUDIES ON PROSTATIC CANCER: II. THE EFFECTS OF CASTRATION ON ADVANCED CARCINOMA OF THE PROSTATE GLAND
The thesis of this work may be briefly summarized. In many instances a malignant prostatic tumor is an overgrowth of adult… 
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