Castration

Known as: Castrations, Surgical Castration, castration surgical 
Surgical removal of the testicles (orchiectomy) or ovaries (oophorectomy) to stop the production of sex hormones. Decreasing the levels of hormones… (More)
National Institutes of Health

Related topics

Related topics

16 relations
Educational aspectsEndocrine systemEunuchismGenitourinary system
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Broader (4)

Endocrine Surgical ProceduresExcisionReproductive systemSexual sterilization

Narrower (1)

Male Castration

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Management of Patients with Advanced Prostate Cancer: The Report of the Advanced Prostate Cancer Consensus Conference APCCC 2017.
BACKGROUND In advanced prostate cancer (APC), successful drug development as well as advances in imaging and molecular… (More)
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Highly Cited
2012
Highly Cited
2012
Abiraterone acetate for treatment of metastatic castration-resistant prostate cancer: final overall survival analysis of the COU-AA-301 randomised, double-blind, placebo-controlled phase 3 study.
BACKGROUND Abiraterone acetate improved overall survival in metastatic castration-resistant prostate cancer at a preplanned… (More)
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Highly Cited
2011
Highly Cited
2011
Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: a randomised, double-blind study
BACKGROUND Bone metastases are a major burden in men with advanced prostate cancer. We compared denosumab, a human monoclonal… (More)
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Highly Cited
2010
Highly Cited
2010
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial
BACKGROUND Cabazitaxel is a novel tubulin-binding taxane drug with antitumour activity in docetaxel-resistant cancers. We aimed… (More)
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Highly Cited
2010
Highly Cited
2010
Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant.
Progression of prostate cancer following castration is associated with increased androgen receptor (AR) expression and signaling… (More)
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Highly Cited
2010
Highly Cited
2010
Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1–2 study
BACKGROUND MDV3100 is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents… (More)
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Highly Cited
2008
Highly Cited
2008
Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth.
Therapy for advanced prostate cancer centers on suppressing systemic androgens and blocking activation of the androgen receptor… (More)
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Highly Cited
2008
Highly Cited
2008
Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer.
Although systemic androgen deprivation prolongs life in advanced prostate cancer, remissions are temporary because patients… (More)
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Highly Cited
2008
Highly Cited
2008
Phase I clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven.
PURPOSE Studies indicate that castration-resistant prostate cancer (CRPC) remains driven by ligand-dependent androgen receptor… (More)
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Review
2005
Review
2005
Biology of progressive, castration-resistant prostate cancer: directed therapies targeting the androgen-receptor signaling axis.
Prostate cancers that are progressing on medical and surgical therapies designed to ablate the action of androgens continue to… (More)
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