Castration

Known as: Castrations, Surgical Castration, castration surgical 
Surgical removal of the testicles (orchiectomy) or ovaries (oophorectomy) to stop the production of sex hormones. Decreasing the levels of hormones… (More)
National Institutes of Health

Papers overview

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Review
2018
Review
2018
BACKGROUND In advanced prostate cancer (APC), successful drug development as well as advances in imaging and molecular… (More)
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Highly Cited
2012
Highly Cited
2012
BACKGROUND Abiraterone acetate improved overall survival in metastatic castration-resistant prostate cancer at a preplanned… (More)
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Highly Cited
2011
Highly Cited
2011
BACKGROUND Bone metastases are a major burden in men with advanced prostate cancer. We compared denosumab, a human monoclonal… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND Cabazitaxel is a novel tubulin-binding taxane drug with antitumour activity in docetaxel-resistant cancers. We aimed… (More)
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Highly Cited
2010
Highly Cited
2010
Progression of prostate cancer following castration is associated with increased androgen receptor (AR) expression and signaling… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND MDV3100 is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents… (More)
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Highly Cited
2008
Highly Cited
2008
Therapy for advanced prostate cancer centers on suppressing systemic androgens and blocking activation of the androgen receptor… (More)
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Highly Cited
2008
Highly Cited
2008
Although systemic androgen deprivation prolongs life in advanced prostate cancer, remissions are temporary because patients… (More)
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Highly Cited
2008
Highly Cited
2008
PURPOSE Studies indicate that castration-resistant prostate cancer (CRPC) remains driven by ligand-dependent androgen receptor… (More)
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Review
2005
Review
2005
Prostate cancers that are progressing on medical and surgical therapies designed to ablate the action of androgens continue to… (More)
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