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Canfosfamide

Known as: (2R)-L-gamma-Glutamyl-3-((2-((bis(bis(2-chloroethyl)amino)phosphinyl)oxy)ethyl)sulfonyl)-L-alanyl-2-phenylglycine 
A modified glutathione analogue and nitrogen mustard prodrug, with potential antineoplastic activity. Canfosfamide is selectively activated by… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
  • B. Freidlin, E. Korn
  • Journal of clinical oncology : official journal…
  • 2014
  • Corpus ID: 13053966
TO THE EDITOR: Most phase III randomized clinical trials (RCT) in oncology are designed to change clinical practice by… Expand
2013
2013
Canfosfamide (TLK286, TELCYTA) is a prodrug that upon activation by glutathione transferase P1-1 (GST P1-1) yields an anticancer… Expand
Review
2012
Review
2012
The vulnerability of some cancer cells to oxidative signals is a therapeutic target for the rational design of new anticancer… Expand
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2010
2010
BackgroundCanfosfamide is a novel glutathione analog activated by glutathione S-transferase P1-1. This study evaluated the safety… Expand
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2009
2009
Introduction: We aimed to evaluate the safety and efficacy of canfosfamide in combination with carboplatin and paclitaxel as… Expand
2009
2009
  • M. Markman
  • Nature Reviews Clinical Oncology
  • 2009
  • Corpus ID: 32946940
Meier and coauthors found that topotecan improved progression-free and overall survival compared with treosulfan in patients with… Expand
Review
2009
Review
2009
5552 Background: Canfosfamide (C) is a glutathione analog prodrug activated by glutathione S-transferase P1-1. C is synergistic… Expand
2007
2007
LBA5528 Background: Canfosfamide (C) is a novel glutathione analog prodrug activated by glutathione S-transferase P1–1. P… Expand
Review
2007
Review
2007
LBA5529 Background: Canfosfamide (C) is a novel glutathione analog prodrug activated by glutathione S-transferase P1–1. C has… Expand