Canfosfamide

Known as: (2R)-L-gamma-Glutamyl-3-((2-((bis(bis(2-chloroethyl)amino)phosphinyl)oxy)ethyl)sulfonyl)-L-alanyl-2-phenylglycine 
A modified glutathione analogue and nitrogen mustard prodrug, with potential antineoplastic activity. Canfosfamide is selectively activated by… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2009-2013
02420092013

Papers overview

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2013
2013
Canfosfamide (TLK286, TELCYTA) is a prodrug that upon activation by glutathione transferase P1-1 (GST P1-1) yields an anticancer… (More)
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2011
Review
2011
The vulnerability of some cancer cells to oxidative signals is a therapeutic target for the rational design of new anticancer… (More)
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2010
2010
BACKGROUND Canfosfamide is a novel glutathione analog activated by glutathione S-transferase P1-1. This study evaluated the… (More)
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2010
Review
2010
OBJECTIVE To evaluate the safety and efficacy of canfosfamide in combination with pegylated liposomal doxorubicin (PLD) in… (More)
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2010
Review
2010
Ovarian cancer is a difficult to treat cancer entity with a high relapse rate. After initial surgery and chemotherapy, only a few… (More)
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2009
2009
RATIONALE Canfosfamide HCl (CAN) is a glutathione analogue prodrug that is activated by glutathione S-transferase P1-1 and… (More)
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2009
2009
INTRODUCTION We aimed to evaluate the safety and efficacy of canfosfamide in combination with carboplatin and paclitaxel as first… (More)
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2009
Review
2009
5552 Background: Canfosfamide (C) is a glutathione analog prodrug activated by glutathione S-transferase P1-1. C is synergistic… (More)
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Review
2009
Review
2009
the current chemotherapeutic standardof-care in the primary management of patients with advanced epithelial ovarian cancer has… (More)
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