Candidate Disease Gene

Known as: Candidate Gene, Candidate Genes, Target Gene 
A gene proposed to have a primary role in a disease, based upon its known function in other organisms or model systems or based upon its physical… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1984-2018
01000200019842018

Papers overview

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Review
2016
Review
2016
Mineral nitrogen fertilization has improved crop yield over the last century but has also caused air and water pollution… (More)
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Highly Cited
2011
Highly Cited
2011
Network "guilt by association" (GBA) is a proven approach for identifying novel disease genes based on the observation that… (More)
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Highly Cited
2009
Highly Cited
2009
ToppGene Suite (http://toppgene.cchmc.org; this web site is free and open to all users and does not require a login to access) is… (More)
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Highly Cited
2008
Highly Cited
2008
Deciphering the genetic basis of human diseases is an important goal of biomedical research. On the basis of the assumption that… (More)
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Highly Cited
2007
Highly Cited
2007
Nicotine dependence is one of the world's leading causes of preventable death. To discover genetic variants that influence risk… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND AND AIMS microRNAs (miRNAs) are short noncoding RNAs that regulate gene expression negatively. Although a role for… (More)
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Highly Cited
2005
Highly Cited
2005
MicroRNAs (miRNAs) are generated by a two-step processing pathway to yield RNA molecules of approximately 22 nucleotides that… (More)
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Highly Cited
2003
Highly Cited
2003
RNA interference is thought to require near-identity between the small interfering RNA (siRNA) and its cognate mRNA. Here, we… (More)
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Highly Cited
2003
Highly Cited
2003
The mammalian unfolded protein response (UPR) protects the cell against the stress of misfolded proteins in the endoplasmic… (More)
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Highly Cited
1998
Highly Cited
1998
The adenomatous polyposis coli gene (APC) is a tumor suppressor gene that is inactivated in most colorectal cancers. Mutations of… (More)
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