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Cancer Stemness Kinase Inhibitor BBI503
Known as:
BBI503
An orally available cancer cell stemness kinase inhibitor with potential antineoplastic activity. Even though the exact target has not been fully…
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National Institutes of Health
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Related topics
1 relation
NCIt Antineoplastic Agent Terminology
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
LncGata6-controlled stemness in regeneration and cancer.
Youn-Sang Jung
,
M. Kim
,
Jae-Il Park
Non-coding RNA Investigation
2019
Corpus ID: 73495706
Long-noncodingRNAs (lncRNAs) have been proposed as a critical regulator of various cellularprocesses including cell fate decision…
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2017
2017
Abstract 20512: Metabolic Reprogramming of Cardiac Progenitor Cells by Lin28 Enhances Cardiac Repair Potential
P. Zaveri
,
D. Harlamova
,
Sadia Mohsin
,
S. Houser
,
Mohsin Khan
2017
Corpus ID: 190885026
Introduction: Cardiac progenitor cells (CPCs) possess incredible repair properties in the neonatal heart but are prone to disease…
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Review
2016
Review
2016
Clinical and molecular insights into adenoid cystic carcinoma: Neural crest‐like stemness as a target
W. Yarbrough
,
A. Panaccione
,
Michael T. Chang
,
S. Ivanov
Laryngoscope Investigative Otolaryngology
2016
Corpus ID: 25133253
This review surveys trialed therapies and molecular defects in adenoid cystic carcinoma (ACC), with an emphasis on neural crest…
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2015
2015
Phase 1 extension study of BBI503, a first-in-class cancer stemness kinase inhibitor, in patients with advanced colorectal cancer.
D. Jonker
,
S. Laurie
,
+17 authors
C. Li
2015
Corpus ID: 87365814
3615 Background: Targeting cancer stem cells (CSC) has shown pre-clinical efficacy and holds therapeutic promise. BBI503 is a…
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2015
2015
Hyperglycemic Stress Impairs the Stemness Capacity of Kidney Stem Cells in Rats
Guang Yang
,
Yali Jia
,
Chunlin Li
,
Q. Cheng
,
W. Yue
,
X. Pei
PLoS ONE
2015
Corpus ID: 16831123
The incidence of acute kidney injury in patients with diabetes is significantly higher than that of patients without diabetes…
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2015
2015
Abstract P2-06-05: Expression of the pluripotency transcription factor SOX2 in primary breast cancers (BCs): Correlation with clinicopathological features (CPfs) and recurrence
B. Pistilli
,
G. Benedetti
,
+10 authors
U. Galderisi
2015
Corpus ID: 70579252
BACKGROUND SOX2 is one of the pluripotency transcription factors expressed by stem cells, which plays a central role in…
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