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National Institutes of Health
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To expand the rich genetic toolkit of Drosophila melanogaster, we evaluated whether introducing FRT or LoxP sites in endogenous…
Mutations in the RNA binding protein Fused in sarcoma (FUS) are estimated to account for 5-10% of all inherited cases of…
In humans, mutations in the fused in sarcoma (FUS) gene have been identified in sporadic and familial forms of amyotrophic…
Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease that leads invariably to fatal paralysis…
BackgoundAmyotrophic lateral sclerosis (ALS) is progressive neurodegenerative disease characterized by the loss of motor function…
Mutations in the fused in sarcoma/translated in liposarcoma gene (FUS/TLS, FUS) have been identified in sporadic and familial…
We have previously described a partial Drosophila cDNA, clone P19, which bears homology to members of the RNA recognition motif…