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Cabeza

 
National Institutes of Health

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2018
2018
FUS causes synaptic hyperexcitability in Drosophila dendritic arborization neurons
Mutations in the nuclear localization signal of the RNA binding protein FUS cause both Frontotemporal Dementia (FTD) and… Expand
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2018
2018
Xrp1 genetically interacts with the ALS-associated FUS orthologue caz and mediates its toxicity
Cabeza (caz) is the single Drosophila melanogaster orthologue of the human FET proteins FUS, TAF15, and EWSR1, which have been… Expand
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2015
2015
Highly efficient cell-type-specific gene inactivation reveals a key function for the Drosophila FUS homolog cabeza in neurons
To expand the rich genetic toolkit of Drosophila melanogaster, we evaluated whether introducing FRT or LoxP sites in endogenous… Expand
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2014
2014
Genetic link between Cabeza, a Drosophila homologue of Fused in Sarcoma (FUS), and the EGFR signaling pathway.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease that causes progressive muscular weakness. Fused in… Expand
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2014
2014
The ALS gene FUS regulates synaptic transmission at the Drosophila neuromuscular junction.
Mutations in the RNA binding protein Fused in sarcoma (FUS) are estimated to account for 5-10% of all inherited cases of… Expand
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2014
2014
Identification of ter94, Drosophila VCP, as a strong modulator of motor neuron degeneration induced by knockdown of Caz, Drosophila FUS.
In humans, mutations in the fused in sarcoma (FUS) gene have been identified in sporadic and familial forms of amyotrophic… Expand
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Highly Cited
2013
Highly Cited
2013
Defects in Synapse Structure and Function Precede Motor Neuron Degeneration in Drosophila Models of FUS-Related ALS
Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease that leads invariably to fatal paralysis… Expand
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Highly Cited
2012
Highly Cited
2012
Motor neuron apoptosis and neuromuscular junction perturbation are prominent features in a Drosophila model of Fus-mediated ALS
BackgoundAmyotrophic lateral sclerosis (ALS) is progressive neurodegenerative disease characterized by the loss of motor function… Expand
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Highly Cited
2012
Highly Cited
2012
Knockdown of the Drosophila Fused in Sarcoma (FUS) Homologue Causes Deficient Locomotive Behavior and Shortening of Motoneuron Terminal Branches
Mutations in the fused in sarcoma/translated in liposarcoma gene (FUS/TLS, FUS) have been identified in sporadic and familial… Expand
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Highly Cited
1995
Highly Cited
1995
Cabeza, a Drosophila gene encoding a novel RNA binding protein, shares homology with EWS and TLS, two genes involved in human sarcoma formation.
We have previously described a partial Drosophila cDNA, clone P19, which bears homology to members of the RNA recognition motif… Expand
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