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Mutations in CYP4F22 cause autosomal recessive congenital ichthyosis (ARCI). However, less than 10% of all ARCI patients carry a… Expand Autosomal recessive congenital ichthyosis (ARCI) is a heterogeneous group of rare disorders of keratinization characterized by… Expand Autosomal recessive congenital ichthyosis (ARCI) caused by mutations in CYP4F22 is very rare. CyP4F22, a protein of the… Expand Autosomal recessive congenital ichthyosis (ARCI) is a clinically and genetically heterogeneous group of keratinization disorders… Expand Significance The sphingolipid backbone ceramide is the major lipid species in the stratum corneum and plays a pivotal function in… Expand  Negi M, Tsuboi R, Matsui T, Ogawa H. Isolation and characterization from Candida albicans: substrate specificity. J Invest… Expand Background Mutations in six genes have been identified in autosomal recessive congenital ichthyosis (ARCI). To date, few studies… Expand Cytochrome P450s are superfamily of heme proteins which generally monooxygenate hydrophobic compounds. The human cytochrome P450… Expand CYP4F22 and CYP4F8 are expressed in epidermis, and mutations of CYP4F22 are associated with lamellar ichthyosis. Epoxyalcohols… Expand Congenital recessive ichthyoses (CRI) form a remarkably heterogeneous group of diseases, resulting from mutations in at least… Expand