CYM-5442
National Institutes of Health
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Neuropathic pain correlates with a lesion or other dysfunction in the nervous system. Sphingosine‐1‐phosphate receptor 2 (S1P2…
High-density lipoprotein (HDL) has previously been shown to promote angiogenesis. However, the mechanisms by which HDL enhances…
Objective To improve the synthesis of a novel S1P1 agonist CYM-5442. Methods4-carbonitrile-1-indanone( 1) was prepared from 3-( 2…
Multiple sclerosis (MS) therapies modulate T-cell autoimmunity in the central nervous system (CNS) but may exacerbate latent…