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CYM-5442

National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Combination of sphingosine-1-phosphate receptor 1 (S1PR1) agonist and antiviral drug: a potential therapy against pathogenic influenza virus
The pandemic 2009 influenza A H1N1 virus is associated with significant mortality. Targeting S1PR1, which is known to modulate… Expand
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2019
2019
Sphingosine‐1‐phosphate receptor 2 modulates pain sensitivity by suppressing the ROS‐RUNX3 pathway in a rat model of neuropathy
Neuropathic pain correlates with a lesion or other dysfunction in the nervous system. Sphingosine‐1‐phosphate receptor 2 (S1P2… Expand
2018
2018
High-density lipoprotein (HDL) promotes angiogenesis via S1P3-dependent VEGFR2 activation
High-density lipoprotein (HDL) has previously been shown to promote angiogenesis. However, the mechanisms by which HDL enhances… Expand
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2017
2017
The S1P1 receptor‐selective agonist CYM‐5442 protects retinal ganglion cells in endothelin‐1 induced retinal ganglion cell loss
ABSTRACT We investigated the feasibility and efficacy of using a specific sphingosine 1–phosphate (S1P1) receptor agonist, CYM… Expand
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2017
2017
Progression of type 1 diabetes from the prediabetic stage is controlled by interferon-α signaling
Significance Type 1 diabetes (T1D) is an increasing medical health problem caused by autoimmune T cells killing insulin-producing… Expand
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2015
2015
The S1P1 receptor-selective agonist CYM-5442 reduces the severity of acute GVHD by inhibiting macrophage recruitment
FTY720, an agonist for four of the five known sphingosine-1-phosphate (S1P) receptors, has been reported to inhibit acute graft… Expand
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2015
2015
Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3
BackgroundSphingosine-1-phosphate (S1P) is a bioactive sphingolipid that acts through a family of five G-protein-coupled… Expand
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Highly Cited
2014
Highly Cited
2014
The Development and Maintenance of Paclitaxel-induced Neuropathic Pain Require Activation of the Sphingosine 1-Phosphate Receptor Subtype 1*
Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a critical dose-limiting side effect of many chemotherapeutic… Expand
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Highly Cited
2012
Highly Cited
2012
S1P1 Receptor Modulation with Cyclical Recovery from Lymphopenia Ameliorates Mouse Model of Multiple Sclerosis
Multiple sclerosis (MS) therapies modulate T-cell autoimmunity in the central nervous system (CNS) but may exacerbate latent… Expand
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Highly Cited
2008
Highly Cited
2008
Full Pharmacological Efficacy of a Novel S1P1 Agonist That Does Not Require S1P-Like Headgroup Interactions
Strong evidence exists for interactions of zwitterionic phosphate and amine groups in sphingosine-1 phosphate (S1P) to conserved… Expand
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