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CWC25 gene

Known as: CWC25, CWC25 spliceosome-associated protein homolog, FLJ20291 
 
National Institutes of Health

Papers overview

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2019
2019
Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching
Pre-mRNA splicing is executed by the spliceosome. Structural characterization of the catalytically activated complex (B∗) is… Expand
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2019
2019
Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching
Summary Pre-mRNA splicing is executed by the spliceosome. Structural characterization of the catalytically activated complex (B… Expand
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2017
2017
A central role of Cwc25 in spliceosome dynamics during the catalytic phase of pre-mRNA splicing.
Splicing of precursor mRNA occurs via two consecutive steps of transesterification reaction; both require ATP and several… Expand
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2014
2014
Remodeling of U2-U6 snRNA helix I during pre-mRNA splicing by Prp16 and the NineTeen Complex protein Cwc2
Removal of intron regions from pre-messenger RNA (pre-mRNA) requires spliceosome assembly with pre-mRNA, then subsequent… Expand
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Highly Cited
2013
Highly Cited
2013
Biased Brownian ratcheting leads to pre-mRNA remodeling and capture prior to first-step splicing
The spliceosome is a dynamic ribonucleoprotein (RNP) machine that catalyzes the removal of introns during the two… Expand
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Highly Cited
2011
Highly Cited
2011
DEAH-box ATPase Prp16 has dual roles in remodeling of the spliceosome in catalytic steps.
The assembly of the spliceosome involves dynamic rearrangements of interactions between snRNAs, protein components, and the pre… Expand
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Highly Cited
2009
Highly Cited
2009
Cwc25 is a novel splicing factor required after Prp2 and Yju2 to facilitate the first catalytic reaction.
Cwc25 has previously been identified to associate with pre-mRNA splicing factor Cef1/Ntc85, a component of the Prp19-associated… Expand
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