CTS-21166

 
National Institutes of Health

Papers overview

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Review
2014
Review
2014
Potential novel targets for Alzheimer pharmacotherapy: II. Update on secretase inhibitors and related approaches.
WHAT IS KNOWN AND OBJECTIVE The prevailing theory regarding Alzheimer disease (AD) is that insoluble amyloid β-peptide (Aβ) plays… (More)
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2010
2010
Bis(7)-tacrine derivatives as multitarget-directed ligands: Focus on anticholinesterase and antiamyloid activities.
A vast array of drug discovery research focuses on the development of innovative drugs targeting Alzheimer’s disease (AD) and… (More)
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Review
2009
Review
2009
Disease-modifying approach to the treatment of Alzheimer's disease: from alpha-secretase activators to gamma-secretase inhibitors and modulators.
In the last decade, advances in understanding the neurobiology of Alzheimer's disease (AD) have translated into an increase in… (More)
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Review
2009
Review
2009
Beyond the neurotransmitter-focused approach in treating Alzheimer's disease: drugs targeting beta-amyloid and tau protein.
Drugs currently used to treat Alzheimer's Disease (AD) have limited therapeutic value and do not affect the main… (More)
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Review
2009
Review
2009
Progress in the development of beta-secretase inhibitors for Alzheimer's disease.
Since the original identification of BACE in 1999 and until quite recently, BACE was often regarded as a "difficult" drug target… (More)
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