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CTC1 gene

Known as: conserved telomere capping protein 1, FLJ22170, CONSERVED TELOMERE MAINTENANCE COMPONENT 1 
National Institutes of Health

Papers overview

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2018
2018
Pathogenic CTC1 mutations cause global genome instabilities under replication stress
Abstract Coats plus syndrome is a complex genetic disorder that can be caused by mutations in genes encoding the CTC1–STN1–TEN1… 
Highly Cited
2017
Highly Cited
2017
CTC1-mediated C-strand fill-in is an essential step in telomere length maintenance
To prevent progressive telomere shortening as a result of conventional DNA replication, new telomeric DNA must be added onto the… 
Highly Cited
2016
Highly Cited
2016
A POT1 mutation implicates defective telomere end fill-in and telomere truncations in Coats plus
In this study, Takai et al. found that Coats plus, a fatal childhood disorder, is a telomere disease. They found that the POT1… 
2016
2016
STN1 OB Fold Mutation Alters DNA Binding and Affects Selective Aspects of CST Function
Mammalian CST (CTC1-STN1-TEN1) participates in multiple aspects of telomere replication and genome-wide recovery from replication… 
2015
2015
Stn1 is critical for telomere maintenance and long-term viability of somatic human cells
Disruption of telomere maintenance pathways leads to accelerated entry into cellular senescence, a stable proliferative arrest… 
2014
2014
POT1a and Components of CST Engage Telomerase and Regulate Its Activity in Arabidopsis
Protection of Telomeres 1 (POT1) is a conserved nucleic acid binding protein implicated in both telomere replication and… 
2014
2014
CTC1 increases the radioresistance of human melanoma cells by inhibiting telomere shortening and apoptosis
Melanoma has traditionally been viewed as a radioresistant cancer. However, recent studies suggest that under certain clinical… 
2012
2012
ATR cooperates with CTC1 and STN1 to maintain telomeres and genome integrity in Arabidopsis
Telomeres protect chromosome ends from DNA damage. CTC1/STN1/TEN1 (CST), a core telomere-capping complex in plant and vertebrates… 
Highly Cited
2009
Highly Cited
2009
Conserved telomere maintenance component 1 interacts with STN1 and maintains chromosome ends in higher eukaryotes.
2009
2009
Single-cell vs. bulk activity properties of coastal bacterioplankton over an annual cycle in a temperate ecosystem.
The connections between single-cell activity properties of heterotrophic planktonic bacteria and whole community metabolism are… 
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