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CRL4(CRBN) E3 Ubiquitin Ligase Modulator CC-220

Known as: CC 220, CC-220 
A modulator of the E3 ubiquitin ligase complex containing cereblon (CRL4-CRBN E3 ubiquitin ligase), with immunomodulating and pro-apoptotic… 
National Institutes of Health

Papers overview

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2019
2019
A Phase 1b/2a Study of the CELMoD Iberdomide (CC-220) in Combination With Dexamethasone in Patients with Relapsed/Refractory Multiple Myeloma
2019
2019
S1603 FIRST CLINICAL (PHASE 1B/2A) STUDY OF IBERDOMIDE (CC-220; IBER), A CELMOD, IN COMBINATION WITH DEXAMETHASONE IN PATIENTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA
Review
2019
Review
2019
[Cereblon as a primary target of IMiDs].
Various derivatives of thalidomide, a drug that is well-known for its teratogenicity, have recently been developed; among them… 
2017
2017
SAT0225 Cereblon modulator CC-220 decreases naÏve and memory B cells and plasmacytoid dendritic cells in systemic lupus erythematosus (SLE) patients: exposure-response results from a phase 2A proof…
Background CC-220 is a cereblon E3 ligase modulatory compound currently in development for the treatment of Systemic Lupus… 
Review
2017
Review
2017
Recent topics in IMiDs and cereblon.
Immunomodulatory drugs (IMiDs) are a new class of anticancer compounds that are derived from thalidomide. Lenalidomide and… 
2017
2017
SAT0255 A randomized, placebo-controlled, double-blind, ascending-dose, safety study of CC-220 in subjects with systemic lupus erythematosus
Background CC-220 is a CUL4CRBN E3 ubiquitin ligase modulator that binds to cereblon and leads to potent and deep reduction of… 
2015
2015
OP0119 The CRL4 Cereblon E3 Ubiquitin Ligase Modulator CC-220 Induces Degradation of the Transcription Factors Aiolos and Ikaros: Immunomodulation in Healthy Volunteers and Relevance to Systemic…
Background CC-220 is an immunomodulatory compound that binds to cereblon (CRBN), part of the CRL4CRBN E3 ubiquitin ligase complex… 
2015
2015
AB0040 Effects of CC-220, A CRL4 Cereblon E3 Ubiquitin Ligase Modulator, on Immune Responses
Background Cereblon (CRBN) is a component of the E3 ubiquitin ligase complex, including cullin 4A, DNA damage binding protein 1… 
2015
2015
AB0041 B-Cell Proliferation and Plasmablast Generation from Naive and Memory B Cells Are Differentially Regulated by Baff, IL-21, and CD40L and Inhibited by the Systemic Lupus Erythematosus Drug…
Background Systemic lupus erythematosus (SLE) is a B-cell-driven autoimmune disease that leads to long-term chronic inflammation… 
2012
2012
Targeting Cereblon with the High Affinity Immunomodulatory Compound CC-220: A Novel Therapeutic Agent for B Cell Dyscrasias
Abstract 1055 Background: Cereblon (CRBN) is a component of the E3 ubiquitin ligase complex including CUL4A, DDB1, and ROC-1, and… 
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