FAQ

CRISPR-Associated Protein Complex Proteins

Known as: CASCADE Proteins, CRISPR Associated, CASCADE Proteins, CRISPR-Associated, CRISPR-Associated Complex for Antiviral Defense Proteins 
Proteins in RIBONUCLEOPROTEIN assemblies of CRISPR-CAS SYSTEMS that function in targeting DNA of invading viruses and plasmids.
National Institutes of Health

Topic mentions per year

Topic mentions per year

2007-2017
05020072017

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CRISPR-Associated Proteins

Related mentions per year

Related mentions per year

2007-2018
20002005201020152020
CRISPR-Associated Protein Complex Proteins
CRISPR-Associated Proteins

Papers overview

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Highly Cited
2015
Highly Cited
2015
Unbiased detection of off-target cleavage by CRISPR-Cas9 and TALENs using integrase-defective lentiviral vectors
The utility of CRISPR-Cas9 and TALENs for genome editing may be compromised by their off-target activity. We show that integrase… (More)
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Highly Cited
2015
Highly Cited
2015
Digenome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells
Although RNA-guided genome editing via the CRISPR-Cas9 system is now widely used in biomedical research, genome-wide target… (More)
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Highly Cited
2015
Highly Cited
2015
CRISPRscan: designing highly efficient sgRNAs for CRISPR/Cas9 targeting in vivo
CRISPR-Cas9 technology provides a powerful system for genome engineering. However, variable activity across different single… (More)
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Highly Cited
2015
Highly Cited
2015
Rapid and highly efficient mammalian cell engineering via Cas9 protein transfection.
CRISPR-Cas9 systems provide a platform for high efficiency genome editing that are enabling innovative applications of mammalian… (More)
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Highly Cited
2012
Highly Cited
2012
CRISPR Interference Directs Strand Specific Spacer Acquisition
BACKGROUND CRISPR/Cas is a widespread adaptive immune system in prokaryotes. This system integrates short stretches of DNA… (More)
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Highly Cited
2011
Highly Cited
2011
Mature clustered, regularly interspaced, short palindromic repeats RNA (crRNA) length is measured by a ruler mechanism anchored at the precursor processing site.
Precise RNA processing is fundamental to all small RNA-mediated interference pathways. In prokaryotes, clustered, regularly… (More)
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Highly Cited
2009
Highly Cited
2009
RNA-Guided RNA Cleavage by a CRISPR RNA-Cas Protein Complex
Compelling evidence indicates that the CRISPR-Cas system protects prokaryotes from viruses and other potential genome invaders… (More)
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Highly Cited
2009
Highly Cited
2009
Short motif sequences determine the targets of the prokaryotic CRISPR defence system.
Clustered regularly interspaced short palindromic repeats (CRISPR) and their associated CRISPR-associated sequence (CAS) proteins… (More)
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Highly Cited
2008
Highly Cited
2008
CRISPR interference limits horizontal gene transfer in staphylococci by targeting DNA.
Horizontal gene transfer (HGT) in bacteria and archaea occurs through phage transduction, transformation, or conjugation, and the… (More)
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Highly Cited
2008
Highly Cited
2008
Diversity, activity, and evolution of CRISPR loci in Streptococcus thermophilus.
Clustered regularly interspaced short palindromic repeats (CRISPR) are hypervariable loci widely distributed in prokaryotes that… (More)
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