CPI 613

Known as: Alpha-Lipoic Acid Analogue CPI-613, CPI-613, CPI613 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2011-2018
02420112018

Papers overview

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2018
2018
Purpose: CPI-613, a lipoate analogue that inhibits pyruvate dehydrogenase (PDH) and α-ketogluterate dehydrogenase (KGDH), has… (More)
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2017
2017
BACKGROUND Pancreatic cancer statistics are dismal, with a 5-year survival of less than 10%, and more than 50% of patients… (More)
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2017
2017
Here, we found that formate, an essential one-carbon metabolite, activates superoxide (O2·-)/hydrogen peroxide (H2 O2 ) release… (More)
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2016
2016
BACKGROUND Small cell lung cancer (SCLC) is a common lung cancer which presents with extensive stage disease at time of diagnosis… (More)
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2014
2014
PURPOSE The lipoate derivative CPI-613 is a first-in-class agent that targets mitochondrial metabolism. This study determined the… (More)
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2014
2014
BACKGROUND Targeting cancer cell metabolism is recognized as a promising arena for development of cancer chemotherapeutics… (More)
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2014
2014
STUDY RATIONALE AND OBJECTIVES Via genetic alterations, malignant transformation and proliferation are associated with extensive… (More)
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2011
2011
CPI-613 is a novel anti-tumor compound with a mechanism-of-action which appears distinct from the current classes of anti-cancer… (More)
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2011
2011
We report the analysis of CPI-613, the first member of a large set of analogs of lipoic acid (lipoate) we have investigated as… (More)
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2011
2011
6590 Background: Acute myeloid leukemia (AML) is an aggressive malignancy of the bone marrow. AML disproportionally affects the… (More)
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