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CP 690,550

Known as: CP-690550, CP-690,550, CP690550 
National Institutes of Health

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1 relation

Broader (1)

tofacitinib

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
THU0131 Tofacitinib (CP-690,550), an oral janus kinase inhibitor: Analysis of malignancies across the rheumatoid arthritis clinical programme
Background Tofacitinib (CP-690,550) is a novel, oral Janus kinase inhibitor that is being investigated as a targeted… 
Review
2011
Review
2011
Targeting JAK3 in kidney transplantation: current status and future options
Purpose of reviewThis review will discuss the mechanism of action and important clinical trial data in renal transplantation for… 
Review
2010
Review
2010
Are Th17 Cells an Appropriate New Target in the Treatment of Rheumatoid Arthritis?
Th17 cells play crucial roles not only in host defense but also in many human autoimmune diseases and corresponding animal models… 
2010
2010
Population Pharmacokinetic Analysis of Mycophenolic Acid Coadministered With Either Tasocitinib (CP-690,550) or Tacrolimus in Adult Renal Allograft Recipients
Tasocitinib (CP-690,550) is an orally active Janus kinase inhibitor that is in development for prophylaxis of acute rejection… 
2009
2009
Chapter 12 Advances in the Discovery of Small Molecule JAK3 Inhibitors
2006
2006
Janus kinase 3 inhibition with CP‐690,550 prevents allograft vasculopathy
Janus kinase 3 (JAK3) mediates signal transduction from cytokine receptors using the common γ chain. The rationally designed… 
Review
2006
Review
2006
Immunotherapy for De Novo renal transplantation: what's in the pipeline?
Immunosuppressive drugs have been traditionally developed to prevent acute rejection and to improve short-term kidney transplant… 
Highly Cited
2005
Highly Cited
2005
Effects of JAK3 Inhibition with CP-690,550 on Immune Cell Populations and Their Functions in Nonhuman Primate Recipients of Kidney Allografts
Background. Janus Kinase (JAK) 3 is a tyrosine kinase essential for proper signal transduction downstream of selected cytokine… 
2005
2005
Quantitative Analysis of the Immunosuppressant CP-690,550 in Whole Blood by Column-Switching High-Performance Liquid Chromatography and Mass Spectrometry Detection
A fast and accurate method to quantify the new immunosuppressive JAK3 inhibitor CP-690,550 in whole blood using a dual-pump… 
Review
2003
Review
2003
JAK3 inhibition as a new concept for immune suppression.
Although current immunosuppressive drugs are effective, they have numerous severe side effects that mandate the search for new… 
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