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Lasofoxifene [CP 336156] is a potent, nonsteroidal, tissue-selective estrogen receptor modulator (SERM). It has the bone-sparing… Expand Neuroprotective effects of estradiol are well characterized in animal experimental models. However, in humans, the outcome of… Expand Selective estrogen receptor modulators (SERMs) are estrogen receptor (ER) ligands that function as antagonists in some tissues… Expand Estrogen replacement therapy is reported to reduce the incidence of vertebral fractures in postmenopausal women, however, its… Expand The purpose of this study was to evaluate if long‐term (6 months) treatment with lasofoxifene (LAS), a new selective estrogen… Expand Selective oestrogen receptor modulators (SERMs) are structurally diverse non-steroidal compounds that bind to oestrogen receptors… Expand It has been well documented that selective estrogen receptor modulators (SERMs) can prevent bone loss in ovariectomized rats and… Expand Chemical modi®cations of the synthetic stilbene nucleus of diethylstilboestrol led to the non-toxic triphenylethylene, tamoxifen… Expand We have discovered a new, nonsteroidal, potent estrogen agonist/antagonist, CP-336,156. CP-336,156 binds selectively and with… Expand We have discovered a new, nonsteroidal, potent estrogen agonist/antagonist, CP-336,156. CP-336,156 binds selectively and with… Expand