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CP-122721

Known as: CP 122,721, CP 122721, CP-122,721 
National Institutes of Health

Papers overview

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2013
2013
NK1 receptor antagonism lowers occupancy requirement for antidepressant-like effects of SSRIs in the Gerbil forced swim test
2007
2007
In vitro metabolism of CP-122,721 ((2S,3S)-2-phenyl-3-[(5-trifluoromethoxy-2-methoxy)benzylamino]piperidine), a non-peptide antagonist of the substance P receptor.
The metabolism of CP-122,721, a neurokinin-1 antagonist, has been examined in vitro using hepatic microsomes from human and… 
2007
2007
Metabolism and excretion of CP-122,721, a non-peptide antagonist of the neurokinin NK1 receptor, in dogs: Identification of the novel cleaved product 5-trifluoromethoxy salicylic acid in plasma
The metabolism and excretion of a potent and selective substance P receptor antagonist, CP-122,721, have been studied in beagle… 
2006
2006
Metabolism, pharmacokinetics and excretion of a potent tachykinin NK1 receptor antagonist (CP-122,721) in rat: Characterization of a novel oxidative pathway
The metabolism, pharmacokinetics and excretion of a potent and selective substance P receptor antagonist, (+)-(2S,3S)-3-(2… 
2004
2004
Diphenidol has no actual broad antiemetic activity in dogs and ferrets.
Previous studies showed that diphenidol was effective on emetogens-induced pica, eating of non-nutritive substances, in rats, a… 
2004
2004
Attenuation of the effects of light on nocturnal melatonin production in humans by the selective NK1 receptor antagonist CP-122,721
2000
2000
CP-122721 prevents postoperative vomiting
  • 2000
  • Corpus ID: 195149760
1998
1998
Chronic non-peptide neurokinin receptor antagonist treatment alters striatal tachykinin peptide and receptor gene expression in the rat
1997
1997
Determination of the substance P receptor antagonist CP-122,721 in plasma by narrow-bore high-performance liquid chromatography-ionspray tandem mass spectrometry.
  • A. KamelC. Prakash
  • Journal of Chromatography B: Biomedical Sciences…
  • 1997
  • Corpus ID: 21535453
1997
1997
An Explanation for the Increasing Incidence of Testis Cancer : Decreasing Age at First Full-Term Pregnancy
sodes (mean, two versus seven) (P 4 .007). Six (86%) of the seven patients who received one dose of CP-122,721 alone as… 
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