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Early pharmacological treatment has the potential to reduce some of the disabling cognitive and behavioral problems that result… Expand Summary Focal cerebral contusions can be dynamic and expansive, leading to delayed neurological deterioration. Due to the high… Expand OBJECTIVE
To test the effect of a novel bradykinin antagonist, deltibant (CP-0127), on survival, organ dysfunction, and other… Expand OBJECTIVE To test the effect of a novel bradykinin antagonist, deltibant (CP-0127), on survival, organ dysfunction, and other… Expand Isolated rabbit hearts in a modified Langendorff preparation were used to study the role of bradykinin B2-receptor antagonism on… Expand In order to investigate the contribution of kinin receptor antagonism in the treatment of LPS-induced shock we conducted a… Expand We studied the effects of CP-0127, a novel bradykinin receptor antagonist, in a rat model of traumatic shock. Pentobarbital… Expand The bradykinin antagonist dimer CP-0127 was found to be a potent and selective inhibitor of the depressor response to bradykinin… Expand