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Purpose Alterations in collagen type IV, alpha-3 (COL4A3) and collagen type IV, alpha-4 (COL4A4) genes may be responsible for a… Expand In the early stage of diabetic nephropathy (one of the major microvascular complications of diabetes) glomerular hyperfiltration… Expand BACKGROUND
Alport syndrome is a clinically and genetically heterogeneous nephropathy. The majority of cases are transmitted as an… Expand We demonstrate a physiological role for tumstatin, a cleavage fragment of the α3 chain of type IV collagen (Col IVα3), which is… Expand We demonstrate a physiological role for tumstatin, a cleavage fragment of the alpha3 chain of type IV collagen (Col IValpha3… Expand Vascular endothelial growth factor (VEGF), a major factor mediating endothelial cell survival, migration, and proliferation… Expand Tumstatin is a 28-kilodalton fragment of type IV collagen that displays both anti-angiogenic and proapoptotic activity. Here we… Expand
Bone marrow does not contribute substantially to endothelial-cell replacement in transplant arteriosclerosis
Components of vascular basement membrane are involved in regulating angiogenesis. Recently, tumstatin (the NC1 domain of α3 chain… Expand Vascular basement membrane is an important regulator of angiogenesis and undergoes many alterations during angiogenesis and these… Expand