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CLCA1 gene

Known as: CHLORIDE CHANNEL, CALCIUM-ACTIVATED, 1, CLCA1, GOB5 
National Institutes of Health

Related topics

Related topics

1 relation
CLCA2 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2020
Highly Cited
2020
Continuous evolution of SpCas9 variants compatible with non-G PAMs
The targeting scope of Streptococcus pyogenes Cas9 (SpCas9) and its engineered variants is largely restricted to protospacer… 
Highly Cited
2017
Highly Cited
2017
Cryo-EM structures of the TMEM16A calcium-activated chloride channel
Calcium-activated chloride channels (CaCCs) encoded by TMEM16A control neuronal signalling, smooth muscle contraction, airway and… 
Highly Cited
2014
Highly Cited
2014
Measures of gene expression in sputum cells can identify TH2-high and TH2-low subtypes of asthma.
Highly Cited
2010
Highly Cited
2010
TMEM16A Inhibitors Reveal TMEM16A as a Minor Component of Calcium-activated Chloride Channel Conductance in Airway and Intestinal Epithelial Cells*
TMEM16A (ANO1) functions as a calcium-activated chloride channel (CaCC). We developed pharmacological tools to investigate the… 
Review
2009
Review
2009
Anoctamin/TMEM16 family members are Ca2+‐activated Cl− channels
Ca2+‐activated Cl− channels (CaCCs) perform many important functions in cell physiology including secretion of fluids from acinar… 
Highly Cited
2009
Highly Cited
2009
Transmembrane Protein 16A (TMEM16A) Is a Ca2+-regulated Cl– Secretory Channel in Mouse Airways*
For almost two decades, it has been postulated that calcium-activated Cl– channels (CaCCs) play a role in airway epithelial Cl… 
Highly Cited
2008
Highly Cited
2008
Expression Cloning of TMEM16A as a Calcium-Activated Chloride Channel Subunit
Highly Cited
2008
Highly Cited
2008
Small-Molecule Screen Identifies Inhibitors of a Human Intestinal Calcium-Activated Chloride Channel
Calcium-activated chloride channels (CaCCs) are widely expressed in mammalian tissues, including intestinal epithelia, where they… 
Review
1999
Review
1999
A tale of three fingers: the family of mammalian Sp/XKLF transcription factors.
One of the most common regulatory elements is the GC box and the related GT/CACC box, which are widely distributed in promoters… 
Highly Cited
1998
Highly Cited
1998
Genomic cloning, molecular characterization, and functional analysis of human CLCA1, the first human member of the family of Ca2+-activated Cl- channel proteins.
We have cloned and molecularly and functionally characterized the first human member of the family of Ca2+-activated Cl- channels… 
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