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CKD 712

Known as: CKD-712, CKD712 
National Institutes of Health

Related topics

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1 relation

Broader (1)

YS 49

Papers overview

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2017
2017
Changes in Cardiac Function After a Single Intravenous Administration of CKD-712 in Healthy Male Volunteers
Background and ObjectivesCKD-712, a candidate treatment for septic shock, acts by increasing cardiac output. This study… 
2017
2017
Development of a LC-MS/MS method for the determination of CKD-712 in rat plasma: Application to a pharmacokinetic study in rats.
2015
2015
Synthesized tetrahydroisoquinoline alkaloid exerts anticancer effects at least in part by suppressing NF-κB-regulated proteins in A549 human lung cancer cells.
CKD-712, a newly synthesized tetrahydroisoquinoline (THI) and an enantiomer (S form) of YS 49 (a derivative of higenamine) has… 
2013
2013
(S)‐1‐α‐naphthylmethyl‐6,7‐dihydroxy‐1,2,3,4‐tetrahydroisoquinoline (CKD712), promotes wound closure by producing VEGF through HO‐1 induction in human dermal fibroblasts and mouse skin
Given the importance of VEGF and haem oxygenase (HO)‐1 in wound healing, the present study tested the hypothesis that CKD712, a… 
2011
2011
Effects of the anti-sepsis drug, (S)-1-(α-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (CKD-712), on mortality, inflammation, and organ injuries in rodent sepsis models
CKD-712 is a 1-naphthyl analog of higenamine that has been reported to have potent antiinflammatory and thus anti-sepsis effects… 
2011
2011
CKD-712, (S)-1-(α-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, Inhibits the NF-κB Activation and Augments Akt Activation during TLR4 Signaling
Since CKD-712 has been developed as an anti-inflammatory agent, we examined the effect of CKD-712 during TLR4 signaling. Using… 
2009
2009
(S)-1-(α-Naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (CKD712) Reduces Rat Myocardial Apoptosis against Ischemia and Reperfusion Injury by Activation of Phosphatidylinositol 3-Kinase…
We examined our hypothesis that (S)-1-(α-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (CKD712) inhibits apoptosis… 
2009
2009
tetrahydroisoquinoline ( CKD 712 ) Reduces Rat Myocardial Apoptosis against Ischemia and Reperfusion Injury by Activation of Phosphatidylinositol 3-Kinase / Akt Signaling and Anti-inflammatory Action…
We examined our hypothesis that (S)-1-( -naphthylmethyl)-6,7dihydroxy-1,2,3,4-tetrahydroisoquinoline (CKD712) inhibits apoptosis… 
2007
2007
The differential role of JAK-2 / STAT-1 in the r egulation of lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 productions by CKD712
2389 Inflammation is commonly associated with carcinogenesis. CKD712, an S enantiomer of YS 49, is under phase I clinical trial… 
2004
2004
THE EFFECTS OF CKD-712, A NOVEL TETRAHYDROISOQUINOLINE DERIVATIVE ON THE DISSEMINATED INTRAVASCULAR COAGULATION (DIC) INDUCED BY LIPOPOLYSACCHARIDE (LPS) IN ANIMALS: 477
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