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CKD 516

Known as: CKD-516, CKD516, Tubulin Polymerization Inhibitor CKD-516 
A benzophenone derivative and water soluble valine prodrug of the tubulin binding agent S516, with potential tubulin-inhibiting, vascular-disrupting… 
National Institutes of Health

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Related topics

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Microtubule Process

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Phase I and pharmacokinetic study of the vascular‐disrupting agent CKD‐516 (NOV120401) in patients with refractory solid tumors
We report a phase I pharmacological study of an oral formulation of CKD‐516, a vascular‐disrupting agent, in patients with… 
2020
2020
Involvement of ER stress and reactive oxygen species generation in anti-cancer effect of CKD-516 for lung cancer
Purpose CKD-516 (Valecobulin), a vascular-disrupting agent, inhibits microtubule elongation. We evaluated the effect of CKD-516… 
2014
2014
Enhanced efficacy of CKD-516 in combination with doxorubicin: pre-clinical evaluation using a hepatocellular carcinoma xenograft model.
AIM To evaluate the anticancer efficacy of CKD-516, a novel vascular-disrupting agent, alone and in combination with doxorubicin… 
2014
2014
CKD-516 displays vascular disrupting properties and enhances anti-tumor activity in combination with chemotherapy in a murine tumor model
SummaryPurpose CKD-516 is a benzophenone analog in which the B ring is modified by replacement with a carbonyl group. The study… 
2013
2013
Early quantification of the therapeutic efficacy of the vascular disrupting agent, CKD-516, using dynamic contrast-enhanced ultrasonography in rabbit VX2 liver tumors
Purpose: To evaluate the usefulness of dynamic contrast-enhanced ultrasonography (DCE-US) in the early quantification of… 
2013
2013
Dialyse und ethische Probleme beim sehr alten Patienten
ZusammenfassungHintergrundÜber einen Zeitraum von 10 Jahren hat sich die Prävalenz älterer Menschen an der Dialyse verdoppelt… 
2012
2012
Wskaźnik filtracji kłębuszkowej jako marker rokowniczy w ostrych zespołach wieńcowych bez uniesienia odcinka ST
Przewlekla choroba nerek (CKD) jest bardzo rozpowszechnionym schorzeniem wspolistniejącym z wieloma chorobami ukladu sercowo… 
2011
2011
Stanowisko Zespołu Krajowego Konsultanta Medycznego w dziedzinie Nefrologii dotyczące stosowania ketoanalogów aminokwasów i roztworu aminokwasów w leczeniu niedożywienia i zapobieganiu mu u dorosłych…
Zastosowanie diet niskobialkowych lub bardzo niskobialkowych u chorych z przewleklą chorobą nerek (CKD, chronic kidney disease… 
2010
2010
Discovery of a potent tubulin polymerization inhibitor: synthesis and evaluation of water-soluble prodrugs of benzophenone analog.
2010
2010
PENGARUH METILPREDNISOLON DOSIS RENDAH TERHADAP KADAR hs-CRP DAN C3 PADA PASIEN PENYAKIT GINJAL KRONIS STADIUM V PASCA HEMODIALISIS
Latar belakang Mortalitas pasien penyakit ginjal kronik yang menjalani hemodialisa tinggi, 60 % karena komplikasi kardiovaskuler… 
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