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The charged multivesicular body proteins (Chmp1–7) are an evolutionarily conserved family of cytosolic proteins that transiently… Expand Cardiomyocyte proteostasis is mediated by the ubiquitin/proteasome system (UPS) and autophagy/lysosome system and is fundamental… Expand Mutations in the charged multivesicular body protein 2B (CHMP2B) gene cause frontotemporal lobar degeneration. The mutations lead… Expand Frontotemporal lobar degeneration (FTLD) is a heterogeneous group of disorders characterized by disturbances of behavior and… Expand Background: ESCRT proteins catalyze membrane budding and fission away from the cytosol. Results: The ESCRT-III protein CHMP2B… Expand K. E. Funk, R. E. Mrak and J. Kuret (2011) Neuropathology and Applied Neurobiology37, 295–306
Granulovacuolar degeneration (GVD… Expand The highly conserved ESCRT-III complex is responsible for deformation and cleavage of membranes during endosomal trafficking and… Expand Frontotemporal dementia (FTD) is the most common form of dementia before 60 years of age. Rare pathogenic mutations in CHMP2B… Expand The ESCRT (endosomal sorting complex required for transport) pathway is required for terminal membrane fission events in several… Expand Mutation in the CHMP2B gene has been implicated in frontotemporal dementia. The authors screened CHMP2B in patients with ALS and… Expand