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CH5164840

National Institutes of Health

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2 relations

Broader (2)

BenzoquinonesLactams, Macrocyclic

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Assessing the impact of HER2 status on the antitumor activity of an HSP90 inhibitor in human tumor xenograft mice using pharmacokinetic-pharmacodynamic modeling.
The purpose of this study is to assess the impact of human epidermal growth factor receptor 2 (HER2) status on the antitumor… 
2012
2012
Design and synthesis of novel macrocyclic 2-amino-6-arylpyrimidine Hsp90 inhibitors.
2012
2012
Preclinical antitumor activity of the novel heat shock protein 90 inhibitor CH5164840 against human epidermal growth factor receptor 2 (HER2)‐overexpressing cancers
Heat shock protein 90 (Hsp90), a molecular chaperone that plays a significant role in the stability and maturation of client… 
2010
2010
92 The design and synthesis of a novel orally available Hsp90 inhibitor CH5164840
2010
2010
81 Potential clinical application of a novel Heat Shock Protein 90 inhibitor CH5164840: preclinical efficacy in mono therapy and combination therapy
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