CH2

 
National Institutes of Health

Papers overview

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2014
2014
Antibody fragments are emerging as promising biopharmaceuticals because of their relatively small-size and other unique… (More)
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2012
2012
Therapeutic monoclonal antibodies have several advantages over small molecule drugs and small proteins and peptides, including a… (More)
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2011
2011
The immunoglobulin (Ig) constant CH2 domain is critical for antibody effector functions. Isolated CH2 domains are promising… (More)
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Review
2009
Review
2009
Currently, almost all FDA approved therapeutic antibodies (except ReoPro, Lucentis and Cimzia which are Fabs), and the vast… (More)
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Highly Cited
2006
Highly Cited
2006
The relationship between electric charge at a material surface and protein adsorption is essential to understand the mechanism of… (More)
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Highly Cited
2001
Highly Cited
2001
Integrin-linked kinase (ILK) is a multidomain focal adhesion (FA) protein that functions as an important regulator of integrin… (More)
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1995
1995
We have found that amino acid residues necessary for C1q and Fc gamma R binding of human IgG1 are located in the N-terminal… (More)
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1994
1994
Site-directed mutagenesis of a recombinant Fc-hinge fragment has previously been used to identify a region of the murine IgG1… (More)
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1991
1991
Using domain switch chimeric antibodies, we confirm the important role of CH2 in complement activation. In addition, we… (More)
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Highly Cited
1981
Highly Cited
1981
The model of human Fc fragment was refined at 2.9-A resolution. Two different automated procedures for crystallographic… (More)
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