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CGP 28014

Known as: CGP-28014 
 
National Institutes of Health

Papers overview

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2010
2010
BACKGROUND AND PURPOSE Catechol‐O‐methyltransferase (COMT) inhibitors are used in Parkinson's disease in which pain is an… Expand
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Review
1999
Review
1999
[Axelrod et al. (1958)][1] first described the enzyme-catalyzed O- methylation of catecholamines and other catechols in the late… Expand
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1998
1998
Dopamine is a natriuretic hormone that is abundantly synthesized in the kidney and is involved in sodium homeostasis. It is… Expand
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Review
1994
Review
1994
1. The structure of catechol O-methyltransferase (COMT) has been recently characterized and a series of new and selective COMT… Expand
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1994
1994
SummaryA series of new and selective catechol-O-methyltransferase (COMT) inhibitors have been developed. Entacapone, nitecapone… Expand
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1993
1993
The effects of three new, selective inhibitors of catechol O-methylation were compared regarding their potentiation of L-3,4… Expand
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Highly Cited
1992
Highly Cited
1992
1 We compared three new catechol O‐methyltransferase (COMT) inhibitors (OR‐611, Ro 40–7592 and CGP 28014; 10 and 30 mg kg−1, i.p… Expand
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1990
1990
SummaryCGP 28014 (N-(2-pyridone-6-yl)-N′,N′-di-n-propylformamidine) or its methanesulfonate salt CGP 28014 A was suspected to be… Expand
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1990
1990
Methods potentially suitable for the determination of the COMT inhibitory properties of CGP 28014 (N-(2-pyridone-6-yl)-N',N'-di-n… Expand
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1990
1990
CGP 28014 A is a specific inhibitor of catechol-O-methyl transferase (COMT). The effect on COMT was assessed with the levodopa… Expand
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