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CGP 28014

Known as: CGP-28014 
National Institutes of Health

Papers overview

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2010
2010
Inhibitors of catechol‐O‐methyltransferase sensitize mice to pain
BACKGROUND AND PURPOSE Catechol‐O‐methyltransferase (COMT) inhibitors are used in Parkinson's disease in which pain is an… 
1998
1998
Different renal effects of two inhibitors of catechol-O-methylation in the rat: entacapone and CGP 28014.
Dopamine is a natriuretic hormone that is abundantly synthesized in the kidney and is involved in sodium homeostasis. It is… 
Review
1994
Review
1994
General properties and clinical possibilities of new selective inhibitors of catechol O-methyltransferase.
1994
1994
Clinical Potential of Catechol-OMethyltransferase (COMT) Inhibitors as Adjuvants in Parkinson’s Disease
SummaryA series of new and selective catechol-O-methyltransferase (COMT) inhibitors have been developed. Entacapone, nitecapone… 
1993
1993
Effects of three types of catechol O-methylation inhibitors on L-3,4-dihydroxyphenylalanine-induced circling behaviour in rats.
1993
1993
Modulation of rat brain endogenous dopamine metabolism by new inhibitors of catechol O-methyltransferase.
Highly Cited
1992
Highly Cited
1992
Different in vivo properties of three new inhibitors of catechol O‐methyltransferase in the rat
1 We compared three new catechol O‐methyltransferase (COMT) inhibitors (OR‐611, Ro 40–7592 and CGP 28014; 10 and 30 mg kg−1, i.p… 
1990
1990
CGP 28014, a new inhibitor of cerebral catechol-O-methylation with a non-catechol structure
SummaryCGP 28014 (N-(2-pyridone-6-yl)-N′,N′-di-n-propylformamidine) or its methanesulfonate salt CGP 28014 A was suspected to be… 
1990
1990
Effects of the COMT inhibitor, CGP 28014, on plasma homovanillic acid and O-methylation of exogenous L-dopa in the rat.
Methods potentially suitable for the determination of the COMT inhibitory properties of CGP 28014 (N-(2-pyridone-6-yl)-N',N'-di-n… 
1990
1990
Effect of the new selective COMT inhibitor CGP 28014 A on the formation of 3-O-methyldopa (3OMD) in plasma of healthy subjects.
CGP 28014 A is a specific inhibitor of catechol-O-methyl transferase (COMT). The effect on COMT was assessed with the levodopa… 
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