Semantic Scholar uses AI to extract papers important to this topic.
BACKGROUND AND PURPOSE Catechol‐O‐methyltransferase (COMT) inhibitors are used in Parkinson's disease in which pain is an… Expand SummaryCGP 28014 (N-(2-pyridone-6-yl)-N′,N′-di-n-propylformamidine) or its methanesulfonate salt CGP 28014 A was suspected to be… Expand [Axelrod et al. (1958)] first described the enzyme-catalyzed O- methylation of catecholamines and other catechols in the late… Expand Dopamine is a natriuretic hormone that is abundantly synthesized in the kidney and is involved in sodium homeostasis. It is… Expand 1. The structure of catechol O-methyltransferase (COMT) has been recently characterized and a series of new and selective COMT… Expand SummaryA series of new and selective catechol-O-methyltransferase (COMT) inhibitors have been developed. Entacapone, nitecapone… Expand 1 Effects of two new inhibitors of catechol O‐methylation (CGP 28014 and entacapone; 30 mg kg−1, i.p.) were compared by means of… Expand 1 We compared three new catechol O‐methyltransferase (COMT) inhibitors (OR‐611, Ro 40–7592 and CGP 28014; 10 and 30 mg kg−1, i.p… Expand Methods potentially suitable for the determination of the COMT inhibitory properties of CGP 28014 (N-(2-pyridone-6-yl)-N',N'-di-n… Expand CGP 28014 A is a specific inhibitor of catechol-O-methyl transferase (COMT). The effect on COMT was assessed with the levodopa… Expand