CG200745

Known as: HDAC inhibitor CG200745 
A histone deacetylase (HDAC) inhibitor with potential antineoplastic activity. CG200745 inhibits the catalytic activity of HDAC, resulting in an… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2008-2016
0120082016

Papers overview

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2017
2017
Pancreatic cancer is predominantly lethal, and is primarily treated using gemcitabine, with increasing resistance. Therefore… (More)
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2017
2017
Cholangiocarcinoma is a devastating malignancy with fatal complications that exhibits low response and resistance to chemotherapy… (More)
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2017
2017
Backgrounds Since most patients with castration-resistant prostate cancer (CRPC) develop resistance to its standard therapy… (More)
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2016
2016
CG200745 is a novel inhibitor of histone deacetylases (HDACs), initially developed for treatment of various hematological and… (More)
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2015
2015
Histone modification plays a pivotal role on gene regulation, as regarded as global epigenetic markers, especially in tumor… (More)
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2015
2015
Purpose The aim of the present study was to assess the safety, maximum tolerated dose (MTD), pharmacokinetics, pharmacodynamics… (More)
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2014
2014
BACKGROUND Epigenetic programming, dynamically regulated by histone acetylation, may play a key role in the pathophysiology of… (More)
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2011
2011
We synthesized a novel hydroxamate-based pan-histone deacetylase inhibitor (HDACI), CG200745 {(E)-2-(Naphthalen-1-yloxymethyl… (More)
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2010
2010
Histone deacetylase (HDAC) plays an important role in cancer onset and progression. Therefore, inhibition of HDAC offers… (More)
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2008
2008
Forming and removing epigenetic histone marks at gene loci are central processes in differentiation. Here, we explored mechanisms… (More)
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